Transient elastography:: a valid alternative to biopsy in patients with chronic liver disease
Transient elastography:: a valid alternative to biopsy in patients with chronic liver disease
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DOI：
10.1111/j.1365-2036.2006.02999.x
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发表时间：
2006-08-01
影响因子：
7.6
通讯作者：
Moreno-Otero, R.
中科院分区：
文献类型：
--
作者：
Gomez-Dominguez, E.;Mendoza, J.;Moreno-Otero, R.
瞬时弹性成像是一种新的、非侵入性的评估慢性肝病纤维化的技术。为了评价瞬时弹性成像技术的有效性、客观性、重复性和安全性，我们收集了103例在过去48个月中接受肝活检的慢性肝病患者。中位硬度值(以千帕斯卡-kpa表示)作为肝脏弹性模数的代表。轻、中度纤维化(FI和FII)和重度纤维化或肝硬化组(FII和FIV)的硬度中位值分别为7，4+/-5和16，4+/-10kPa，两者之间有显著差异(P<；0.05)。受试者工作特征曲线下的面积显示了每组的最佳肝脏硬度分界值。我们发现，在所有患者中，瞬时弹性成像所发现的肝脏硬度与肝活检的纤维化分期呈正相关，与肝脏疾病的病因无关。瞬时弹性成像是一种简单、快速和安全的非侵入性方法，可可靠地评估肝纤维化。
Transient elastography is a novel and non-invasive technique for the evaluation of fibrosis in chronic liver disease. Few studies that exist value the efficacy of transient elastography, mainly in hepatitis C virus-infected patients.To evaluate the effectiveness, objectivity, reproducibility and safety of this technique.We included 103 consecutive patients who underwent a liver biopsy in the last 48 months with a wide spectrum of chronic liver diseases. Median stiffness value (expressed as kilopascals - kPa) was kept as representative of the liver elastic modulus. All biopsy specimens were analysed by the same pathologist according to the METAVIR scoring system.Median value of stiffness in patients with mild or moderate fibrosis (FI and FII), and severe fibrosis or cirrhosis (FIII and FIV) was of 7, 4 +/- 5 and 16, 4 +/- 10 kPa, respectively, with a significant difference between them (P < 0.05). The areas under the receiver operating characteristic curves showed the optimal liver stiffness cut-off values for each group.We found a positive correlation between the liver stiffness found by transient elastography and fibrosis stage on biopsy in all patients, independently of the liver disease aetiology. Transient elastography is an easy, quick to perform and safe non-invasive procedure, reliable for assessing liver fibrosis.