A research agenda for malaria eradication: basic science and enabling technologies.
A research agenda for malaria eradication: basic science and enabling technologies.
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DOI：
10.1371/journal.pmed.1000399
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发表时间：
2011-01-25
期刊：
影响因子：
15.8
通讯作者：
malERA Consultative Group on Basic Science and Enabling Technologies
中科院分区：
文献类型：
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作者：
malERA Consultative Group on Basic Science and Enabling Technologies
根除疟疾研究议程（malERA）基础科学和使能技术咨询小组提出了根除疟疾所需基础研究的研究和开发议程。由于我们对疟原虫的生物学以及人类与多种蚊子和寄生虫之间的复杂关系的不完全了解，当今的疟疾控制工作受到限制。研究重点包括开发恶性疟原虫和间日疟原虫整个生命周期的体外培养系统，以及开发适当的肝脏培养系统来研究肝脏阶段。此外，需要改进操纵疟原虫的遗传技术，需要对整个寄生虫代谢组进行表征，以确定新的药物靶标，并改进信息系统，以监测由于加强控制而导致的流行病学、病理学和宿主-寄生虫-载体相互作用的变化，以弥合实验室、临床前、临床和基于人群的科学之间的差距。
The Malaria Eradication Research Agenda (malERA) consultative group on Basic Science and Enabling Technologies present a research and development agenda for basic research required for malaria eradication. Today's malaria control efforts are limited by our incomplete understanding of the biology of Plasmodium and of the complex relationships between human populations and the multiple species of mosquito and parasite. Research priorities include the development of in vitro culture systems for the complete life cycle of P. falciparum and P. vivax and the development of an appropriate liver culture system to study hepatic stages. In addition, genetic technologies for the manipulation of Plasmodium need to be improved, the entire parasite metabolome needs to be characterized to identify new druggable targets, and improved information systems for monitoring the changes in epidemiology, pathology, and host-parasite-vector interactions as a result of intensified control need to be established to bridge the gap between bench, preclinical, clinical, and population-based sciences.