Association between air pollution and lung function growth in Southern California children - Results from a second cohort
Association between air pollution and lung function growth in Southern California children - Results from a second cohort
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DOI：
10.1164/rccm.2111021
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发表时间：
2002-07-01
影响因子：
24.7
通讯作者：
Peters, JM
中科院分区：
文献类型：
--
作者：
Gauderman, WJ;Gilliland, GF;Peters, JM
1996年，一组1678名南加州四年级儿童接受了为期4年的跟踪调查，以确定这些儿童的肺功能增长是否与他们暴露在环境空气污染物中有关。这些受试者组成了参加儿童健康研究的第二批四年级儿童。暴露于酸性蒸气、NO2、空气动力学直径小于2.5微米(PM2.5)的颗粒(PM2.5)和元素碳与肺功能增长率的显著缺陷有关。例如，在观察到的酸暴露范围内，最大呼气中段流量和1秒用力呼气量的年平均增长率分别下降了约11%(p=0.005)和5%(p=0.03)。暴露于酸性蒸气也与最大呼吸中段流量与用力肺活量的比率降低有关(p=0.02)，而暴露于臭氧则与峰值流速的增长减少相关(p=0.006)。在报告花更多时间在户外的儿童中，观察到肺功能增长率的更大缺陷。这些发现重要地重复了我们以前的发现，即空气污染对肺功能生长的影响，这些发现基于儿童健康研究(Am J Respir Crit Care Med 2000；162：1383-1390)的第一个四年级队列。
A cohort of 1,678 Southern California children, enrolled as fourth graders in 1996, was followed for 4 years to determine whether the growth in lung function of the children was associated with their exposure to ambient air pollutants. These subjects comprised the second cohort of fourth grade children participating in the Children's Health Study. Significant deficits in lung function growth rate were associated with exposure to acid vapor, NO2, particles with aerodynamic diameter less than 2.5 mum (PM2.5), and elemental carbon. For example, the average annual growth rates of maximal midexpiratory flow and forced expiratory volume in I second were reduced by approximately 11% (p = 0.005) and 5% (p = 0.03), respectively, across the observed range of acid exposure. Exposure to acid vapor was also associated with reductions in the ratio of maximal midexpiratory flow to forced vital capacity (p = 0.02), whereas exposure to ozone was correlated with reduced growth in peak flow rate (p = 0.006). Larger deficits in lung function growth rate were observed in children who reported spending more time outdoors. These findings provide important replication of our previous findings of an effect of air pollution on lung function growth that were based on the first fourth-grade cohort from the Children's Health Study (Am J Respir Crit Care Med 2000;162:1383-1390).