Nutritional Ketosis Alters Fuel Preference and Thereby Endurance Performance in Athletes
Nutritional Ketosis Alters Fuel Preference and Thereby Endurance Performance in Athletes
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DOI：
10.1016/j.cmet.2016.07.010
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发表时间：
2016-08-09
期刊：
影响因子：
29
通讯作者：
Clarke, Kieran
中科院分区：
文献类型：
--
作者：
Cox, Pete J.;Kirk, Tom;Clarke, Kieran
酮症是对能量危机的代谢反应，是通过改变氧化燃料选择来维持生命的机制。酮病的代谢潜力常常被忽视，除了饥饿或糖尿病危象外，人们对酮病的了解很少。因此，我们研究了使用酮酯为基础的营养形式，没有不必要的环境中的内源性酮体生产热量或碳水化合物限制的酮症在人类中的生化优势。在对39名高性能运动员的五项独立研究中，我们展示了这种独特的代谢状态如何通过改变氧化呼吸的燃料竞争来提高身体耐力。酮症降低肌肉糖酵解和血浆乳酸浓度，同时提供了一个替代底物氧化磷酸化。在运动过程中，酮症增加肌内三酰甘油氧化，即使在存在正常的肌糖原，共同摄入的碳水化合物和胰岛素升高。这些发现可能为更大的人类潜力和更好地理解健康和疾病中的燃料代谢提供线索。
Ketosis, the metabolic response to energy crisis, is a mechanism to sustain life by altering oxidative fuel selection. Often overlooked for its metabolic potential, ketosis is poorly understood outside of starvation or diabetic crisis. Thus, we studied the biochemical advantages of ketosis in humans using a ketone ester-based form of nutrition without the unwanted milieu of endogenous ketone body production by caloric or carbohydrate restriction. In five separate studies of 39 high-performance athletes, we show how this unique metabolic state improves physical endurance by altering fuel competition for oxidative respiration. Ketosis decreased muscle glycolysis and plasma lactate concentrations, while providing an alternative substrate for oxidative phosphorylation. Ketosis increased intramuscular triacylglycerol oxidation during exercise, even in the presence of normal muscle glycogen, co-ingested carbohydrate and elevated insulin. These findings may hold clues to greater human potential and a better understanding of fuel metabolism in health and disease.