Comprehensive analysis of Helicobacter pylori infection-associated diseases based on miRNA-mRNA interaction network.
Comprehensive analysis of Helicobacter pylori infection-associated diseases based on miRNA-mRNA interaction network.
复制标题
基于miRNA-mRNA相互作用网络综合分析幽门螺杆菌感染相关疾病
DOI：
10.1093/bib/bby018
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发表时间：
2019-07-19
影响因子：
9.5
通讯作者：
Zhou J
中科院分区：
文献类型：
--
作者：
Yang J;Song H;Cao K;Song J;Zhou J
摘要幽门螺杆菌(H.Pylori)感染在世界范围内仍是一个重要的致病和死亡原因。全面了解幽门螺杆菌的致病机制及其与宿主的相互作用将有助于开发新的预防和治疗策略。在这里，我们首先使用miRNA数据集测定了幽门螺杆菌感染的胃炎、十二指肠溃疡、胃癌或粘膜相关淋巴组织淋巴瘤患者的microRNA(MiRNA)水平。鉴定了34个差异表达的miRNAs，并对这些miRNA靶基因进行了功能富集性分析，结果表明，H.Pylori感染与肿瘤的发生途径和mRNA合成的调控密切相关。通过对28个HUB基因的疾病连通性分析，我们发现幽门螺杆菌可能会增加许多胃外疾病(如心血管疾病、血液和淋巴疾病以及神经系统疾病)的风险。综上所述，我们的综合分析为基于miRNA-mRNA相互作用网络的病原体-人类疾病连接性预测提供了一种新的方法，并显示了抗H.幽门螺杆菌治疗是预防人类疾病的有效手段。
Abstract Helicobacter pylori (H. pylori) infection remains a cause of significant morbidity and mortality worldwide. Comprehensive understanding of the pathogenic mechanism of H. pylori and its interaction with host will contribute to developing novel prophylactical and therapeutical strategies. Here, we first determined microRNA (miRNA) levels in H. pylori-infected patients with gastritis, duodenal ulcer, gastric cancer or mucosa-associated lymphoid tissue lymphoma using miRNA data sets. Thirty-four differentially expressed miRNAs were identified and functional enrichment analysis of those miRNA target genes revealed that H. pylori infection were strongly associated with pathway in cancer and regulation of mRNA synthesis. Using disease connectivity analysis of 28 hub genes, we found that H. pylori may increase the risk of many extragastric diseases (e.g. cardiovascular disease, hemic and lymphatic diseases and nervous system disease). Altogether, our integrated analysis provided a new method to predict pathogen–human disease connectivity based on miRNA-mRNA interaction network and indicated anti-H. pylori therapy as an effective means of human diseases prevention.
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作者：
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通讯作者：
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