Selective portal blood flow diversion in auxiliary partial orthotopic liver transplantation to induce regeneration of the graft.
Selective portal blood flow diversion in auxiliary partial orthotopic liver transplantation to induce regeneration of the graft.
复制标题
辅助部分原位肝移植中选择性门静脉血流转向以诱导移植物再生。
DOI：
10.1097/00007890-199810150-00022
复制
发表时间：
1998
期刊：
影响因子：
6.2
通讯作者：
K. Tanaka
中科院分区：
文献类型：
--
作者：
M. Kaibori;H. Egawa;Y. Inomata;S. Uemoto;K. Asonuma;T. Kiuchi;G. Varela;T. Matsukura;M. Kasahara;K. Uryuhara;A. Inui;H. Komatsu;T. Fujisawa;K. Tanaka
辅助性部分原位肝移植（APOLT）的经验仍然非常有限，许多问题仍有待解决。在这篇文章中，我们提出的情况下，一个5岁的女孩与鸟氨酸转氨甲酰酶缺乏症谁最初做好后APOLT。在移植后16个月的一次严重排斥反应中，她出现了脑病和高氨血症。尽管抗排斥治疗的临床和组织病理学反应良好，但移植物变小，自体肝脏发生代偿性肥大。在我们手术结扎右门静脉分支后，移植物恢复，患者能够在术后1个月停止用药。我们估计，正常肝脏的最小体积需要纠正的代谢缺陷，在鸟氨酸转氨甲酰酶缺乏症是8立方厘米/公斤。结扎门静脉右分支是一种安全有效的方法，可以使肥大的自体肝逐渐退化，并使萎缩的移植肝再生。
Experience with auxiliary partial orthotopic liver transplantation (APOLT) is still very limited and many questions remain to be solved. In this article, we present the case of a 5-year-old girl with ornithine transcarbamylase deficiency who initially did well after APOLT. During a severe rejection episode 16 months after transplantation, she developed encephalopathy and hyperammonemia. Despite a good clinical and histopathological response to antirejection therapy, the graft had become smaller and the native liver had undergone compensatory hypertrophy. After we surgically ligated the right portal branch, the graft recovered and the patient was able to stop her medication 1 month after surgery. We have estimated that the minimum volume of normal liver required to correct the metabolic defect in ornithine transcarbamylase deficiency is 8 cm3/kg. The ligation of the right portal branch was a safe and effective method of inducing a gradual and progressive involution of the hypertrophic native liver and regeneration of the atrophic graft.
S.Uemoto：“在来自活体供体的辅助部分原位肝移植中，移植物与保存的天然肝脏共存，以治疗鸟氨酸转氨甲酰酶缺乏症。”
DOI：
--
发表时间：
--
期刊：
影响因子：
--
作者：
通讯作者：
--