Volumetric reduction of cerebellar lobules associated with memory decline across the adult lifespan
Volumetric reduction of cerebellar lobules associated with memory decline across the adult lifespan
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DOI：
10.21037/qims.2019.10.19
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发表时间：
2020-01-01
影响因子：
2.8
通讯作者：
Qiu, Jianfeng
中科院分区：
文献类型：
--
作者：
Cui, Doug;Zhang, Li;Qiu, Jianfeng
背景：人类小脑在运动控制、认知功能和情绪反应中起着重要作用。然而，人们对小脑小叶与年龄相关的记忆衰退之间的关系知之甚少。我们的目的是研究不同年龄的小脑小叶的体积变化，并评估它们与记忆回忆能力下降的相关性。方法：将275人分为20 ~ 35岁（青年）、36 ~ 50岁（中前期）、51 ~ 65岁（中后期）和66 ~ 89岁（老年）4组。使用volBrain软件获取小脑体积。采用协方差分析和事后分析分析各组小脑小叶体积差异，采用Bonferroni法进行多重比较。采用Spearman相关性研究小叶体积与记忆回忆分数之间的关系。结果：在这项研究中，我们发现老年人的小脑体积比其他受试者小。双侧小叶I和小叶I体积减小，双侧小叶I、小叶VI和右小叶IV体积与记忆回忆得分显著相关。结论：在本研究中，我们发现小脑的一些小叶比其他小叶更容易发生与年龄相关的变化。这些发现提供了进一步的证据，证明小脑的特定区域可以用来评估成年人一生中记忆力下降的风险。
Background: The human cerebellum plays an essential role in motor control, is involved in cognitive function and helps to regulate emotional responses. However, little is known about the relationship between cerebellar lobules and age-related memory decline. We aimed to investigate volume alterations in cerebellar lobules at different ages and assess their correlations with reduced memory recall abilities.Methods: A sample of 275 individuals were divided into the following four groups: 20-35 years (young), 36-50 years (early-middle age), 51-65 years (late-middle age), and 66-89 years (old). Volumes of the cerebellar lobules were obtained using volBrain software. Analysis of covariance and post hoc analysis were used to analyze group differences in cerebellar lobular volumes, and multiple comparisons were performed using the Bonferroni method. Spearman correlation was used to investigate the relationship between lobular volumes and memory recall scores.Results: In this study, we found that older adults had smaller cerebellar volumes than the other subjects. Volumetric decreases in size were noted in bilateral lobule VI and lobule crus I. Moreover, the volumes of bilateral lobule crus I, lobule VI, and right lobule IV were significantly associated with memory recall scores.Conclusions: In the present study, we found that some lobules of the cerebellum appear more predisposed to age-related changes than other lobules. These findings provide further evidence that specific regions of the cerebellum could be used to assess the risk of memory decline across the adult lifespan.