Information and communication theory in molecular biology

Information and communication theory in molecular biology
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分子生物学中的信息与通信理论

DOI:
10.1007/s00202-007-0062-6
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发表时间:
2007
影响因子:
1.8
通讯作者:
Jakob C. Mueller
Jakob C. Mueller
中科院分区:
工程技术4区
文献类型:
--
作者:
P. Hanus;Bernhard Goebel;J. Dingel;J. Weindl;J. Zech;Z. Dawy;J. Hagenauer;Jakob C. Mueller

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过去几年的DNA测序工作以及测序技术的快速发展已经产生了大量的序列数据,这些数据可在公共分子数据库中获得。这一最新的发展使得它在统计上是可行的,从香农的信息理论的问题,在分子生物学,例如,使用互信息的基因定位和系统发育分类的普遍概念。此外,细胞中的遗传信息不断发生突变。然而,它必须以高保真度代代相传,这就提出了是否存在类似于技术通信系统中使用的错误保护和纠正机制的问题。最后,通过寻找与通信理论中已建立的模型的相似之处,可以更好地理解细胞中分子水平上的遗传信息处理,例如,基因表达和帧同步之间存在类比。
The DNA sequencing efforts of the past years together with rapid progress in sequencing technology have generated a huge amount of sequence data available in public molecular databases. This recent development makes it statistically feasible to apply universal concepts from Shannon’s information theory to problems in molecular biology, e.g to use mutual information for gene mapping and phylogenetic classification. Additionally, the genetic information in the cell is continuously subject to mutations. However, it has to be passed from generation to generation with high fidelity, raising the question of existence of error protection and correction mechanisms similar to those used in technical communication systems. Finally, better understanding of genetic information processing on the molecular level in the cell can be acquired by looking for parallels to well established models in communication theory, e.g. there exist analogies between gene expression and frame synchronization.
DOI: 10.1101/gr.3715005
发表时间: 2005-08-01
期刊: GENOME RESEARCH
影响因子: 7
作者:
Siepel, A;Bejerano, G;Haussler, D
通讯作者: Haussler, D
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