Brain activity during biofeedback relaxation - A functional neuroimaging investigation
Brain activity during biofeedback relaxation - A functional neuroimaging investigation
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DOI：
10.1093/brain/124.5.1003
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发表时间：
2001-05-01
期刊：
影响因子：
14.5
通讯作者：
Dolan, RJ
中科院分区：
文献类型：
--
作者：
Critchley, HD;Melmed, RN;Dolan, RJ
认知过程影响身体唤醒状态的机制对于理解应激相关疾病的发病机制和维持是重要的。我们使用PET来研究与交感神经活动的认知驱动调制有关的大脑活动。受试者进行训练，以执行生物反馈放松运动，反映皮肤电活动，随后进行扫描，重复执行四个任务：生物反馈放松，放松没有生物反馈和两个相应的控制条件下，受试者被指示不要放松。放松与左前扣带回和苍白球活动的显著增加相关，而与随机反馈相比，生物反馈的活动没有显著增加。生物反馈和放松之间的相互作用，突出活动独特的生物反馈放松，与增强前扣带回和小脑蚓部活动。这些数据暗示前扣带皮层在身体唤醒的有意调制，并提出了一个功能性神经解剖学的认知状态是如何与身体反应相结合。这一发现可能会对治疗干预（如压力相关疾病的放松训练）如何介导其效果的机制产生影响。
The mechanisms by which cognitive processes influence states of bodily arousal are important for understanding the pathogenesis and maintenance of stress-related morbidity. We used PET to investigate cerebral activity relating to the cognitively driven modulation of sympathetic activity. Subjects were trained to perform a biofeedback relaxation exercise that reflected electrodermal activity and were subsequently scanned performing repetitions of four tasks: biofeedback relaxation, relaxation without biofeedback and two corresponding control conditions in which the subjects were instructed not to relax. Relaxation was associated with significant increases in left anterior cingulate and globus pallidus activity, whereas no significant increases in activity were associated with biofeedback compared with random feedback. The interaction between biofeedback and relaxation, highlighting activity unique to biofeedback relaxation, was associated with enhanced anterior cingulate and cerebellar vermal activity. These data implicate the anterior cingulate cortex in the intentional modulation of bodily arousal and suggest a functional neuroanatomy of how cognitive states are integrated with bodily responses. The findings have potential implications for a mechanistic account of how therapeutic interventions, such as relaxation training in stress-related disorders, mediate their effects.