DEFICITS IN EYE-MOVEMENTS FOLLOWING FRONTAL EYE-FIELD AND SUPERIOR COLLICULUS ABLATIONS
DEFICITS IN EYE-MOVEMENTS FOLLOWING FRONTAL EYE-FIELD AND SUPERIOR COLLICULUS ABLATIONS
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DOI：
10.1152/jn.1980.44.6.1175
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发表时间：
1980-01-01
影响因子：
2.5
通讯作者：
CONWAY, JL
中科院分区：
文献类型：
--
作者：
SCHILLER, PH;TRUE, SD;CONWAY, JL
这项研究调查了额叶视野和上丘消融对注视模式和眼跳运动的影响。猴子被训练从多槽苹果板上摘苹果片，同时它们的头是固定的。主要使用植入搜索线圈方法获得眼球运动记录。单侧和双侧额叶眼野病变仅产生暂时的眼球运动缺陷。手术后，猴子倾向于忽视对侧周边视野，并且对周边目标的扫视次数较少。恢复几乎在 2-4 周内完成。优越的丘消融降低了注视精度、扫视频率和扫视速度。随着时间的推移，这些缺陷几乎没有恢复。成对的额叶视野和上丘病变在视觉触发的眼球运动中产生了显着的缺陷。动物无法再以任何准确度将眼睛固定在视觉目标上。眼球运动的范围大大减少，眼跳的频率和速度也大大减少。随着时间的推移，这些缺陷几乎没有恢复。视觉触发的眼球扫视运动显然是由平行通道控制的，一个涉及上丘，另一个涉及额眼场。
This study investigated the effects of frontal eye-field and superior colliculus ablations on fixation patterns and saccadic eye movements. Monkeys were trained to pick apple pieces out of a multiple-slotted apple board while their heads were fixed. Eye movement records were obtained using predominantly the implanted search-coil method. Both unilateral and bilateral frontal eye-field lesions produced only temporary deficits in eye movements. Following surgery monkeys tended to neglect the contralateral peripheral visual field and made fewer saccades to peripheral targets. Recovery was virtually complete in 2-4 wk. Superior colliculus ablation reduced fixation accuracy, saccade frequency and saccade velocity. These deficits showed little recovery with time. Paired frontal eye-field and superior colliculus lesions produced dramatic deficits in visually triggered eye movements. Animals could no longer fixate their eyes on visual targets with any degree of accuracy. The range of eye movements was greatly reduced, as was the frequency and velocity of saccades. These deficits showed little recovery with time. Visually triggered saccadic eye movements are apparently controlled by parallel channels, 1 involving the superior colliculus and the other the frontal eye field.