SCALING OF RESPIRATORY VARIABLES IN MAMMALS
SCALING OF RESPIRATORY VARIABLES IN MAMMALS
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DOI：
10.1152/jappl.1967.22.3.453
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发表时间：
1967-01-01
影响因子：
3.3
通讯作者：
STAHL, WR
中科院分区：
文献类型：
--
作者：
STAHL, WR
从文献中收集数据，呼吸变量和相关aginast体重的双对数关系（异速生长）的假设与使用计算机回归分析。统计验证的幂律公式，相关系数为0。99-0. 90，显示肺重量、VC[长划线]肺活量、TLC[长划线]总肺活量、FRC[长划线]功能残气量、VT-潮气量、VD、O2、E。f[长划线]呼吸次数/分钟、Cl[长划线]肺顺应性、DLCO-肺的CO扩散能力、DLO 2-肺的O2扩散能力、总呼吸流动阻力、每次呼吸功和几个非呼吸参数。这项研究主要涉及大鼠和人类的大小范围，但预测公式可能涵盖了小鼠和所有哺乳动物。比较了大鼠、猫、犬和人的预测值和观察值;证明了良好的一致性。尺寸无关的无量纲和量纲呼吸不变量或设计参数可以通过从具有接近零的净剩余质量指数（依赖于体重）的个体幂律形成简单和复杂的不变量来获得。
Data were collected from the literature on respiratory variables and cor-related aginast body weight on the assumption of log-log relationships (allometry) with the use of computer regression analysis. Statistically validated power law formulas, with correlation coefficients of 0. 99-0. 90, are presented for lung weight, VC[long dash]vital capacity, TLC[long dash]total lung capacity, FRC[long dash]functional residual capacity, VT-tidal volume, VD, O2, E. f[long dash]number of breaths/min, Cl[long dash]pulmonary compliance, DLCO-Diffusing capacity of the lung for CO, DLO2-Diffusing capacity of the lung for 02, total respiratory flow resistance, work per breath, and several nonrespiratory parameters. The study deals principally with the rat-human size range, but the prediction formulas probably cover mice to steer and possibly all mammals. Predicted and observed values are compared for the rat, cat, dog, and man; good agreement is demonstrated. Size-independent dimensionless and dimensional respiratory invariants or design parameters may be obtained by forming simple and complex quotients from the individual power laws that have net residual mass exponents (dependency on body weight) approaching zero.