THE PHOTOPHYSICAL PROPERTIES OF A RUTHENIUM-SUBSTITUTED PHTHALOCYANINE
THE PHOTOPHYSICAL PROPERTIES OF A RUTHENIUM-SUBSTITUTED PHTHALOCYANINE
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DOI：
10.1016/1011-1344(94)07048-2
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发表时间：
1994-12-01
影响因子：
5.4
通讯作者：
WILSON, BC
中科院分区：
文献类型：
--
作者：
CHARLESWORTH, P;TRUSCOTT, TG;WILSON, BC
采用激光闪光光解、脉冲辐解和时间分辨近红外发光等方法研究了一种新型水溶性金属酞菁化合物的光性能。酞菁通过光动力疗法（PDT）诱导肿瘤大小的显著减小或完全肿瘤根除。然而，尽管该酞菁在甲醇中以0.3的量子产率敏化单线态氧的产生，但在空气饱和的D2O中单线态氧产生的量子产率小于0.01（我们的设备的检测极限）。这可以用酞菁的三重态寿命（在氮饱和的甲醇中为1.2 μ s，在氮饱和的水中为0.65 μ s）和从甲醇到水的氧浓度降低近十倍的组合效应来解释。因此，我们建议，在水溶液中，一个非单线态氧介导的机制，可能是电子转移，占主导地位，并导致观察到的PDT效应。
Laser flash photolysis, pulse radiolysis and time-resolved near-IR luminescence were used to study the photoproperties of a novel water-soluble metallophthalocyanine with no peripheral substitution. The phthalocyanine induces a significant reduction in tumour size or complete tumour eradication by photodynamic therapy (PDT). Yet, although this phthalocyanine sensitizes the production of singlet oxygen with a quantum yield of 0.3 in methanol, the quantum yield of singlet oxygen production in air-saturated D2O is less than 0.01 (the detection limit of our equipment). This is explained in terms of the combined effect of the triplet state lifetime of the phthalocyanine (1.2 mu s in nitrogen-saturated methanol and 0.65 mu s in nitrogen-saturated water) and the near tenfold reduction in the oxygen concentration from methanol to water. Therefore we propose that, in aqueous solution, a non-singlet-oxygen-mediated mechanism, probably electron transfer, prevails and leads to the observed PDT effect.