Frequency analyses of CSF flow on cine MRI in normal pressure hydrocephalus
Frequency analyses of CSF flow on cine MRI in normal pressure hydrocephalus
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DOI：
10.1007/s00330-002-1697-3
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发表时间：
2003-05-01
影响因子：
5.9
通讯作者：
Onoguchi, M
中科院分区：
文献类型：
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作者：
Miyati, T;Mase, M;Onoguchi, M
我们的目的是阐明常压脑积水（NPH）的颅内脑脊液（CSF）流动动力学。采用相衬电影MRI对脑脊液流量进行频率分析。测定了NPH、脑萎缩或无症状心室扩张（VD）患者（n=51）和健康志愿者（n= 25）的脑脊液流谱。同时分析静脉注射乙酰唑胺后脑脊液血流谱的变化。此外，根据驱动血管脉动和脑脊液流的频谱计算相传递函数（PTF）进行了评估。将这些值与压力体积响应（PVR）进行比较。由于依从性降低，NPH组的幅度明显大于VD组或对照组。与VD组和对照组相比，NPH组的阶段有显著差异，但VD组和对照组之间没有差异。注射乙酰唑胺后，各组的振幅均有所增加。NPH组PTF明显大于对照组，PTF与PVR呈正相关。通过电影MRI测量脑脊液流量的频率分析，可以无创地获得更详细的NPH病理生理学图像。
Our objective was to clarify intracranial cerebrospinal fluid (CSF) flow dynamics in normal-pressure hydrocephalus (NPH). Frequency analyses of CSF flow measured with phase-contrast cine MRI were performed. The CSF flow spectra in the aqueduct were determined in patients (n=51) with NPH, brain atrophy or asymptomatic ventricular dilation (VD), and in healthy volunteers (control group; n=25). The changes in CSF flow spectra were also analyzed after intravenous injection of acetazolamide. Moreover, a phase transfer function (PTF) calculated from the spectra of the driving vascular pulsation and CSF flow in the aqueduct were assessed. These values were compared with the pressure volume response (PVR). The amplitude in the NPH group was significantly larger than that in the VD or control group because of a decrease in compliance. The phase in the NPH group was significantly different from that in either the VD or the control group, but no difference was found between the VD and control groups. The amplitude increased in all groups after acetazolamide injection. The PTF in the NPH group was significantly larger than in the control group, and a positive correlation was noted between PTF and PVR. Frequency analyses of CSF flow measured by cine MRI make it possible to noninvasively obtain a more detailed picture of the pathophysiology of NPH.