Postnatal development of the electrophysiological properties of somatostatin interneurons in the anterior cingulate cortex of mice.
Postnatal development of the electrophysiological properties of somatostatin interneurons in the anterior cingulate cortex of mice.
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小鼠前扣带皮层生长抑素中间神经元电生理特性的出生后发育
DOI：
10.1038/srep28137
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发表时间：
2016-06-20
影响因子：
4.6
通讯作者：
Li XM
中科院分区：
文献类型：
--
作者：
Pan G;Yang JM;Hu XY;Li XM
前扣带皮层 (ACC) 中的生长抑素 (SST) 阳性中间神经元在神经元疾病、记忆和认知功能中发挥重要作用。然而，他们在 ACC 的发展仍不清楚。使用出生后第 3 天 (P3) 至 P45 GIN 小鼠，我们发现 ACC 中 SST 中间神经元的大多数内在膜特性在出生后第二周后发育成熟，并且这些神经元的发育与前额叶皮层中的小清蛋白 (PV) 中间神经元的发育不同。此外，SST 中间神经元之间的电耦合主要出现在 P12-14 之间。耦合概率稳定在 P21-30 左右，耦合强度的发展与年龄无关。 SST 中间神经元的兴奋性化学传入的发展早于抑制性化学传入的发展。此外，闭眼减弱了 P21-30 处电耦合概率的发展，但对耦合强度没有影响。闭眼还延迟了抑制性化学传入频率的发展，但对兴奋性化学传入幅度、频率或上升时间没有影响。我们的数据表明，ACC 中的 SST 中间神经元表现出与其他中间神经元亚型（例如 PV 中间神经元）不同的固有发育特征，并且其中一些特征受到环境调节。
Somatostatin (SST)-positive interneurons in the anterior cingulate cortex (ACC) play important roles in neuronal diseases, memory and cognitive functions. However, their development in the ACC remains unclear. Using postnatal day 3 (P3) to P45 GIN mice, we found that most of the intrinsic membrane properties of SST interneurons in the ACC were developmentally mature after the second postnatal week and that the development of these neurons differed from that of parvalbumin (PV) interneurons in the prefrontal cortex. In addition, electrical coupling between SST interneurons appeared primarily between P12–14. The coupling probability plateaued at approximately P21–30, with a non-age-dependent development of coupling strength. The development of excitatory chemical afferents to SST interneurons occurred earlier than the development of inhibitory chemical afferents. Furthermore, eye closure attenuated the development of electrical coupling probability at P21–30 but had no effect on coupling strength. Eye closure also delayed the development of inhibitory chemical afferent frequency but had no effect on the excitatory chemical afferent amplitude, frequency or rise time. Our data suggest that SST interneurons in the ACC exhibit inherent developmental characteristics distinct from other interneuron subtypes, such as PV interneurons and that some of these characteristics are subject to environmental regulation.