The midwife, the coincidence, and the hypothesis
The midwife, the coincidence, and the hypothesis
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DOI：
10.1136/bmj.327.7429.1428
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发表时间：
2003-12-20
影响因子：
--
通讯作者：
Barker, D
中科院分区：
文献类型：
--
作者：
Barker, D
子宫内和婴儿期的不利条件会增加日后患心血管疾病的风险，这一假说的提出需要进行以前从未进行过的流行病学研究。有必要找到至少60年前出生的人的出生体重和婴儿期生活条件的记录，并将这些记录与他们目前的心血管健康状况联系起来。经过几年的搜寻，一大批记录在赫特福德郡被发现。这些收藏的存在是由于一位助产士埃塞尔·玛格丽特伯恩赛德的远见。然而，能够接触到这些记录只是一个幸运的巧合，而随后的研究在今天可能是不可能的。
Development of the hypothesis that adverse conditions in utero and during infancy increase the risk of cardiovascular disease in later life required epidemiological studies of a kind never undertaken before. It was necessary to find records of birth weight and living conditions during infancy for people born at least 60 years ago and to link these to their current cardiovascular health. After a search lasting several years, a large collection of records came to light in Hertfordshire. The existence of this collection was due to the foresight of one midwife, Ethel Margaret Burnside. Getting access to the records, however, was down to a fortunate coincidence, and the subsequent research probably would not be possible today.