Mast cell changes in experimental diabetes: focus on attenuation of allergic events
Mast cell changes in experimental diabetes: focus on attenuation of allergic events
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DOI：
10.1590/s0074-02762005000900021
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发表时间：
2005-03-01
期刊：
影响因子：
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通讯作者：
e Silva, Patrícia MR
中科院分区：
文献类型：
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作者：
Carvalho, Vinicius F;Barreto, Emiliano O;e Silva, Patrícia MR
特应性疾病和糖尿病的患病率在全球范围内不断增加，尽管在个体患者中发现这些病理的并发症比预期的要少。此外，糖尿病和变态反应的共存通常以各自症状的减轻为标志，并且一种疾病的有效治疗会加重另一种疾病。本文综述了关于变态反应和糖尿病的并发症的最新进展，特别关注过敏原诱发的血管和细胞变化的后果。有人提出，肥大细胞数量和反应性的减少可能是互斥现象背后的一个关键机制。
The prevalence of atopic diseases and diabetes is increasing worldwide though the concurrence of these pathologies in individual patients is found less frequent than it would be predicted. Moreover co-existence of diabetes and allergy is generally marked by attenuation of their respective symptoms, and effective treatment of one disease exacerbates the other This review gives an update of the state-of-the-art concerning the intercurrence of allergy and diabetes, particularly focusing on the consequences to the allergen-evoked vascular and cellular changes. It is proposed that the reduction in mast cell numbers and reactivity may be a pivotal mechanism behind the mutual exclusion phenomenon.