EFFECT OF HACHIMIJIOGAN, AN ORIENTAL HERBAL MEDICINAL MIXTURE, ON EXPERIMENTAL AMNESIA IN MICE
EFFECT OF HACHIMIJIOGAN, AN ORIENTAL HERBAL MEDICINAL MIXTURE, ON EXPERIMENTAL AMNESIA IN MICE
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DOI：
10.1248/bpb.17.1182
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发表时间：
1994-09-01
影响因子：
2
通讯作者：
OGIHARA, Y
中科院分区：
文献类型：
--
作者：
HIROKAWA, S;NOSE, M;OGIHARA, Y
采用循序渐进的被动回避失败技术：东莨菪碱、放线菌素和脑缺血诱导的健忘症，研究了八密交感方对认知障碍的影响。Hachimijiogan收购前试验给药(0.5g/kg，p.O.)延长东莨菪碱和环己定缩短的避暗潜伏期。Hachimijiogan(0.5和1.0g/kg，P.O.)还能改善脑缺血所致的记忆障碍。毒扁豆碱(0.1 mg/kg，i.p.)改善了所有三种健忘症模型。Hachimijiogan和毒扁豆碱对放线菌素所致的遗忘症的改善作用可与东莨菪碱合用而减弱。这些结果提示，八味交感方具有广泛的抗记忆作用，其抗记忆作用可能与胆碱能神经系统有关。
The effect of Hachimijiogan on cognitive disturbance was investigated using step-through passive avoidance failure techniques: scopolamine-, cycloheximide- and cerebral ischemia-induced amnesia. Pre-acquisition trial administration of Hachimijiogan (0.5 g/kg, p,o.) prolonged the step-through latency reduced by scopolamine and cyclohexidime. Hachimijiogan (0.5 and 1.0 g/kg, p.o.) also ameliorated the cerebral ischemia-induced amnesia. Physostigmine (0.1 mg/kg, i.p.) ameliorated all three amnesia models. The ameliorating effects of Hachimijiogan and physostigmine on cycloheximide-induced amnesia were diminished by the combination with scopolamine. These results suggest that Hachimijiogan possesses a wide-ranging pharmacological profile in anti-amnesic actions and that its anti-amnesic activities may be refitted to the cholinergic neuronal system.