Changes in quality of life associated with fragility fractures: Australian arm of the International Cost and Utility Related to Osteoporotic Fractures Study (AusICUROS).
Changes in quality of life associated with fragility fractures: Australian arm of the International Cost and Utility Related to Osteoporotic Fractures Study (AusICUROS).
复制标题
DOI：
10.1007/s00198-015-3088-z
复制
发表时间：
2015-06
影响因子：
4
通讯作者：
Sanders, K. M.
中科院分区：
文献类型：
--
作者：
Abimanyi-Ochom, J.;Watts, J. J.;Borgstrom, F.;Nicholson, G. C.;Shore-Lorenti, C.;Stuart, A. L.;Zhang, Y.;Iuliano, S.;Seeman, E.;Prince, R.;March, L.;Cross, M.;Winzenberg, T.;Laslett, L. L.;Duque, G.;Ebeling, P. R.;Sanders, K. M.
我们调查了50岁以上的澳大利亚成年人因骨折而导致的健康相关生活质量的变化。骨折会降低生活质量，至少会持续12个月以上。在人口层面上，损失相当于每个骨折完全健康的65天。我们的目的是使用EQ-5D-3和L问卷来量化骨折导致的健康相关生活质量的变化。从澳大利亚的八个研究中心招募了年龄在≥50岁、患有中低能量骨折的成年人。这项前瞻性研究包括对骨折后2周内招募的参与者进行为期18个月的跟踪调查(髋关节、手腕、肱骨、脊柱和脚踝)。在基线和4个月、12个月和18个月收集的信息包括参与者的特征，如收入水平、教育程度和既往骨折状况。在骨折后12个月，使用多元回归分析评估累积的生活质量损失，以确定HRQOL损失的预测因素。所有参与者骨折前的平均HRQOL为0.86，其中腕部骨折的HRQOL最高(0.90)，而脊柱骨折的HRQOL最低(0.80)。骨折后即刻HRQOL降至0.42。只有手腕、肱骨或脚踝骨折的参与者在18个月后恢复到骨折前的HRQL。在骨折、住院、教育和骨折部位之前，12个月内HRQOL的损失增加与HRQL相关。多元回归解释了所有骨折在骨折后12个月累积HRQOL损失的30%的变化。低到中等能量的骨折会降低HRQOL，这种损失至少会持续12个月，如果是髋部和脊柱骨折，至少会持续18个月。在人口层面上，这意味着每个脆性骨折平均失去65天的完全健康。这一重大负担加强了对具有成本效益的骨折预防战略的需求。本文的在线版本(doi：10.1007/s00198-0153088-z)包含补充材料，授权用户可以使用。
We investigated change in health-related quality of life due to fracture in Australian adults aged over 50 years. Fractures reduce quality of life with the loss sustained at least over 12 months. At a population level, the loss was equivalent to 65 days in full health per fracture. We aimed to quantify the change in health-related quality of life (HRQoL) that occurred as a consequence of a fracture using the EQ-5D-3 L questionnaire. Adults aged ≥50 years with a low to moderate energy fracture were recruited from eight study centres across Australia. This prospective study included an 18-month follow-up of participants recruited within 2 weeks of a fracture (hip, wrist, humerus, vertebral and ankle). Information collected at baseline and 4, 12 and 18 months included characteristics of participants such as income level, education and prior fracture status. At 12 months post-fracture, the cumulative loss of quality of life was estimated using multivariate regression analysis to identify the predictors of HRQoL loss. Mean HRQoL for all participants before fracture was 0.86, with wrist fracture having the highest pre-fracture HRQoL (0.90), while vertebral fracture had the lowest (0.80). HRQoL declined to 0.42 in the immediate post-fracture period. Only participants with a wrist, humerus or ankle fracture returned to their pre-fracture HRQoL after 18 months. An increased loss of HRQoL over 12 months was associated with HRQoL prior to the fracture, hospitalisation, education and fracture site. The multiple regression explained 30 % of the variation in the cumulative HRQoL loss at 12 months post-fracture for all fractures. Low to moderate energy fractures reduce HRQoL, and this loss is sustained for at least 12 months or, in the case of hip and spine fractures, at least 18 months. At a population level, this represents an average loss of 65 days in full health per fragility fracture. This significant burden reinforces the need for cost-effective fracture prevention strategies. The online version of this article (doi:10.1007/s00198-015-3088-z) contains supplementary material, which is available to authorized users.
登录
查看更多内容
影响因子：
4
作者：
Sanders, KM;Seeman, E;Kotowicz, MA
通讯作者：
Kotowicz, MA
影响因子：
105.7
作者：
Salkeld, G;Cameron, ID;Quine, S
通讯作者：
Quine, S
影响因子：
--
作者：
Rancic, Natasa K.;Petrovic, Branislav D.;Ilic, Mirko V.
通讯作者：
Ilic, Mirko V.
影响因子：
4
作者：
Tosteson, ANA;Gabriel, SE;Melton, LJ
通讯作者：
Melton, LJ
影响因子：
3.3
作者：
Brooks, R
通讯作者：
Brooks, R