Trophinin in cell adhesion and signal transduction.
Trophinin in cell adhesion and signal transduction.
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DOI：
10.2741/381
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
M. Fukuda;K. Sugihara
中科院分区：
文献类型：
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作者：
M. Fukuda;K. Sugihara
人类胚胎植入的过程不仅由进化上保守的机制介导，而且由人类特有的活动介导。在后者中，有证据表明细胞粘附分子trophinin在人类胚胎着床中起着独特的作用。在这里，我们描述的营养蛋白质和营养相关蛋白质bystin和tastin的特点。然后，我们描述了滋养外胚层细胞在人类胚胎植入和人类精子尾部运动相关的事件中的营养素介导的信号转导。我们还报告了营养素在人类癌症中的双重作用，在某些肿瘤类型中促进恶性肿瘤，在其他类型中抑制恶性肿瘤。
The process of human embryo implantation is mediated not only by evolutionarily conserved mechanisms but by activities unique to humans. Among the latter, evidence suggests that the cell adhesion molecule trophinin plays a unique role in human embryo implantation. Here, we describe characteristics of trophinin protein and of the trophinin-associated proteins bystin and tastin. We then describe trophinin-mediated signal transduction in trophectoderm cells during human embryo implantation and events related to human sperm tail motility. We also report dual roles for trophinin in human cancers in terms of promoting malignancy in some tumor types and suppressing it in others.