Respiratory neuroplasticity and cervical spinal cord injury: translational perspectives.
Respiratory neuroplasticity and cervical spinal cord injury: translational perspectives.
复制标题
DOI：
10.1016/j.tins.2008.07.002
复制
发表时间：
2008-10
影响因子：
15.9
通讯作者：
Reier, Paul J.
中科院分区：
文献类型：
--
作者：
Lane, Michael A.;Fuller, David D.;White, Todd E.;Reier, Paul J.
膈肌麻痹是颈脊髓损伤的严重后果。这种情况可以通过偏侧的、高位的颈部病变来实验性地模拟，这些病变中断了到相应膈神经核的下行吸气驱动。虽然部分恢复同侧膈肌功能发生随着时间的推移，最近的研究结果表明，持续的慢性缺陷，通气和膈运动神经元的活动。然而，一些证据表明，自发恢复可以通过调节神经通路膈运动神经元通过突触电路，这似乎比以前设想的更复杂。本综述强调了这些和其他最近的实验多学科的研究结果有关的呼吸神经可塑性的大鼠。翻译的考虑也被强调，特别注意针对不同的病变模型和结果的措施的临床和解释的优势。
Paralysis of the diaphragm is a severe consequence of cervical spinal cord injury. This condition can be experimentally modeled by lateralized, high cervical lesions that interrupt descending inspiratory drive to the corresponding phrenic nucleus. Although partial recovery of ipsilateral diaphragm function occurs over time, recent findings show persisting chronic deficits in ventilation and phrenic motoneuron activity. Some evidence suggests, however, that spontaneous recovery can be enhanced by modulating neural pathways to phrenic motoneurons via synaptic circuitries which appear more complex than previously envisioned. The present review highlights these and other recent experimental multi-disciplinary findings pertaining to respiratory neuroplasticity in the rat. Translational considerations are also emphasized, with specific attention directed at the clinical and interpretational strengths of different lesion models and outcome measures.
登录
查看更多内容
影响因子：
82.9
作者：
Courtine, Gregoire;Song, Bingbing;Sofroniew, Michael V.
通讯作者：
Sofroniew, Michael V.
影响因子：
5.3
作者：
Fuller, D. D.;Doperalski, N. J.;Reier, P. J.
通讯作者：
Reier, P. J.
DOI：
10.1073/pnas.262669099
发表时间：
2002-12-24
影响因子：
11.1
作者：
Corbetta, M;Burton, H;McDonald, JW
通讯作者：
McDonald, JW
DOI：
10.1097/01.ta.0000187660.03742.a6
发表时间：
2005-10-01
影响因子：
--
作者：
Como, JJ;Sutton, ERH;Scalea, TM
通讯作者：
Scalea, TM
影响因子：
1.7
作者：
Chiodo, Anthony E.;Scelza, William;Forchheimer, Martin
通讯作者：
Forchheimer, Martin