Triazolam impairs inhibitory control of behavior in humans
Triazolam impairs inhibitory control of behavior in humans
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DOI：
10.1037/1064-1297.9.4.363
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发表时间：
2001-11-01
影响因子：
2.3
通讯作者：
Hays, L
中科院分区：
文献类型：
--
作者：
Fillmore, MT;Rush, CR;Hays, L
这项研究测试了镇静催眠药物三唑仑(Halcion)对人类行为抑制能力的影响。30名成年人参加了一项停止信号任务，该任务测量了他们在选择反应时间任务中抑制和激活行为反应的能力。然后，相同数量的参与者(即，n=10)在双盲条件下接受0.25 mg、0.125 mg或0 mA(安慰剂)的三唑仑，并在3小时内间歇性地执行这项任务。与假设一致，三唑仑减少了反应抑制，并增加了抑制反应所需的时间。该药物还减缓了反应的激活。这些发现有助于理解镇静催眠药物在某些个体中产生行为去抑制状态的基本行为机制。
This study tested the effects of the sedative-hypnotic drug triazolam (Halcion) on the ability to inhibit behavior in humans. Thirty adults practiced a stop-signal task that measured their ability to inhibit and activate behavioral responses on a choice reaction time task. Equal numbers of participants (i.e., n = 10) then received either 0.25 mg, 0.125 mg, or 0 ma (placebo) of triazolam under double-blind conditions and performed the task intermittently over a 3-hr period. In accord with the hypothesis, triazolam reduced response inhibitions and increased the time required to inhibit a response. The drug also slowed the activation of responses. The findings contribute to the understanding of the basic behavioral mechanisms by which sedative-hypnotic drugs can produce states of behavioral disinhibition in some individuals.