Plasmodium falciparum:: in vitro growth inhibition by febrile temperatures
Plasmodium falciparum:: in vitro growth inhibition by febrile temperatures
复制标题
DOI：
10.1007/s004360100374
复制
发表时间：
2001-07-01
影响因子：
2
通讯作者：
Kremsner, PG
中科院分区：
文献类型：
--
作者：
Long, HY;Lell, B;Kremsner, PG
发热发作是疟疾感染的标志。我们测定了高温对恶性疟原虫体外生长的抑制作用。寄生虫在37摄氏度至40摄氏度之间的不同温度下培养4天。在连续培养中，观察到寄生虫血症随温度的变化呈Logistic下降。在寄生虫周期内培养不同时间的同步化培养物显示，随着寄生虫的成熟，生长抑制作用明显增强。高温抑制了寄生虫的生长，疟疾期间长时间的高烧可能有利于寄生虫的清除。
Febrile episodes are the hallmark of malarial infection. We determined the inhibitory effect of febrile temperatures on the in vitro growth of Plasmodium falciparum. Parasites were cultured at various temperatures between 37 degreesC and 40 degreesC for 4 days. A logistic decrease in parasitaemia as a function of temperature was observed for continuous cultures. Incubation of synchronized cultures for different lengths of time during the parasite cycle showed a strong increase of growth inhibition with the maturing of parasites. Febrile temperatures inhibit parasite growth and long, high fevers during malaria may be beneficial for parasite clearance.