The effect of ketanserin on serotonin-induced vascular responses in the isolated perfused rat lung.
The effect of ketanserin on serotonin-induced vascular responses in the isolated perfused rat lung.
复制标题
酮色林对离体灌注大鼠肺中血清素诱导的血管反应的影响。
DOI：
10.1016/0014-2999(89)90024-1
复制
发表时间：
1989
影响因子：
5
通讯作者：
J. Syce
中科院分区：
文献类型：
--
作者：
M. Le Roux;J. Syce
基于5-羟色胺（5-HT）在各种心肺疾病中的血管收缩作用，本文研究了5-HT_2受体拮抗剂酮色林对5-HT诱导的大鼠离体肺反应的影响。5-HT产生双相反应，包括弱的血管扩张和占主导地位的，剂量依赖性的收缩成分。Ketanserin无直接扩血管作用，但能完全拮抗5-HT引起的缩血管反应，提示这种反应是5-HT 2受体介导的。
Based on a vasoconstrictor role for serotonin (5-HT) in various types of cardiopulmonary conditions the effect of the 5-HT2receptor antagonist, ketanserin, on 5-HT-induced responses in the intact, isolated rat lung was investigated. 5-HT produced biphasic responses consisting of weak vasodilator and predominant, dose-dependent constrictor components. Ketanserin showed no direct vasodilator effects but could completely antagonise the 5-HT-induced vasoconstrictor responses, suggesting that this response was 5-HT2receptor-mediated.
离体犬冠状动脉的收缩对 S2 血清素能阻断具有抵抗力。
DOI：
--
发表时间：
1986
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
Cohen,RA
通讯作者：
Cohen,RA