Structure, function, and regulation of desmosomes.
Structure, function, and regulation of desmosomes.
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DOI：
10.1016/b978-0-12-394311-8.00005-4
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发表时间：
2013
影响因子：
--
通讯作者：
Green, Kathleen J.
中科院分区：
文献类型：
--
作者：
Kowalczyk, Andrew P.;Green, Kathleen J.
桥粒是粘附性细胞间连接，其通过将桥粒钙粘蛋白介导的粘附相互作用偶联到中间丝细胞骨架网络来机械地整合相邻细胞。桥粒钙粘蛋白通过密集成簇的细胞质斑块蛋白连接到中间丝，所述细胞质斑块蛋白包含犰狳基因家族的成员，包括斑珠蛋白和斑嗜蛋白，以及细胞连接物的斑蛋白家族的成员，如桥粒斑蛋白。桥粒在组织完整性中的重要性通过由桥粒基因突变、桥粒钙粘蛋白的自身抗体攻击和选择性靶向桥粒钙粘蛋白的细菌毒素引起的人类疾病而突出。除了审查桥粒蛋白在组织完整性的众所周知的作用，本章还强调了越来越多的赞赏如何桥粒蛋白与细胞信号通路的整合，以促进脊椎动物组织的组织和分化。
Desmosomes are adhesive intercellular junctions that mechanically integrate adjacent cells by coupling adhesive interactions mediated by desmosomal cadherins to the intermediate filament cytoskeletal network. Desmosomal cadherins are connected to intermediate filaments by densely clustered cytoplasmic plaque proteins comprising members of the armadillo gene family, including plakoglobin and plakophilins, and members of the plakin family of cytolinkers, such as desmoplakin. The importance of desmosomes in tissue integrity is highlighted by human diseases caused by mutations in desmosomal genes, autoantibody attack of desmosomal cadherins, and bacterial toxins that selectively target desmosomal cadherins. In addition to reviewing the well-known roles of desmosomal proteins in tissue integrity, this chapter also highlights the growing appreciation for how desmosomal proteins are integrated with cell signaling pathways to contribute to vertebrate tissue organization and differentiation.