Humans Can Taste Glucose Oligomers Independent of the hT1R2/hT1R3 Sweet Taste Receptor
Humans Can Taste Glucose Oligomers Independent of the hT1R2/hT1R3 Sweet Taste Receptor
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DOI：
10.1093/chemse/bjw088
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发表时间：
2016-11-01
期刊：
影响因子：
3.5
通讯作者：
Lim, Juyun
中科院分区：
文献类型：
--
作者：
Lapis, Trina J.;Penner, Michael H.;Lim, Juyun
人们普遍认为，人类可以品尝单糖和二糖作为甜味物质，但他们不能品尝更长链的寡糖和多糖。从进化的角度来看，品尝淀粉或其低聚水解产物的能力将是高度适应性的，因为它们具有营养价值。在这里，我们报告说，人类可以品尝葡萄糖低聚物制剂（平均聚合度7和14）没有任何其他感官线索。相同的人类受试者不能品尝相应的葡萄糖聚合物制剂（平均聚合度44）。当甜味受体被已知的甜味抑制剂lactisole阻断时，受试者无法检测到甜味物质（葡萄糖，麦芽糖和三氯蔗糖），但他们仍然可以检测到葡萄糖低聚物。这表明葡萄糖寡聚体检测不依赖于hT 1 R2/hT 1 R3甜味受体。人类受试者将葡萄糖低聚物的味道描述为“淀粉”，而他们将糖描述为“甜”。“葡萄糖低聚物的剂量反应功能也被发现与葡萄糖的摩尔基础上无法区分。
It is widely accepted that humans can taste mono-and disaccharides as sweet substances, but they cannot taste longer chain oligo-and polysaccharides. From the evolutionary standpoint, the ability to taste starch or its oligomeric hydrolysis products would be highly adaptive, given their nutritional value. Here, we report that humans can taste glucose oligomer preparations (average degree of polymerization 7 and 14) without any other sensorial cues. The same human subjects could not taste the corresponding glucose polymer preparation (average degree of polymerization 44). When the sweet taste receptor was blocked by lactisole, a known sweet inhibitor, subjects could not detect sweet substances (glucose, maltose, and sucralose), but they could still detect the glucose oligomers. This suggests that glucose oligomer detection is independent of the hT1R2/ hT1R3 sweet taste receptor. Human subjects described the taste of glucose oligomers as "starchy," while they describe sugars as "sweet." The dose-response function of glucose oligomer was also found to be indistinguishable from that of glucose on a molar basis.