EFFECTS OF DIET CALCIUM AND 1,25-DIHYDROXYVITAMIN-D3 ON COLON CALCIUM ACTIVE-TRANSPORT
EFFECTS OF DIET CALCIUM AND 1,25-DIHYDROXYVITAMIN-D3 ON COLON CALCIUM ACTIVE-TRANSPORT
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DOI：
10.1152/ajpgi.1980.238.2.g75
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发表时间：
1980-01-01
影响因子：
--
通讯作者：
MOND, AE
中科院分区：
文献类型：
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作者：
FAVUS, MJ;KATHPALIA, SC;MOND, AE
在没有电化学梯度的情况下，研究了钙在体外大鼠降结肠段的单向通量。膳食钙限制和1,25-二羟基维生素D3[1,25-(OH)2D3]通过增加粘膜到浆膜的通量来增强吸收；分泌（血清-粘膜）通量没有变化。低钙饮食刺激升、降结肠外翻肠囊段对钙的吸收；横结肠无反应。结肠是125 -(OH)2D3的靶器官。结肠参与肠道对钙缺乏的适应。
Unidirectional fluxes of Ca were studied in the absence of electrochemical gradients across rat descending colon segments in vitro. Dietary Ca restriction and 1,25-dihydroxyvitamin D3[1,25-(OH)2D3] enhanced absorption by increasing the mucosal-to-serosal fluxes; secretory (serosal-to-mucosal) fluxes were unchanged. Low-Ca diet stimulated Ca uptake by everted gut sac segments of ascending and descending colon; transverse colon was unresponsive. The colon is a target organ for 1,25-(OH)2D3. The colon participates in the intestinal adaptation to Ca deprivation.