Effects of voluntary exercise on apoptosis and cortisol after chronic restraint stress in mice.
Effects of voluntary exercise on apoptosis and cortisol after chronic restraint stress in mice.
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DOI：
10.20463/jenb.2016.09.20.3.3
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发表时间：
2016-09
期刊：
影响因子：
--
通讯作者：
Ryu S
中科院分区：
文献类型：
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作者：
Seo H;Park CH;Choi S;Kim W;Jeon BD;Ryu S
确定自愿运动（轮跑）是否具有缓解压力的潜力。 在这项研究中，对单独笼子里的小鼠进行了有或没有自愿轮跑的约束应激。总共 21 只 ICR 雄性小鼠被分配到对照组 (CON)、有自愿运动的约束应激 (RSVE) 或无自愿运动的约束应激 (RS) 组（每组 n = 7）。 尽管 CON 和 RS 组与 RSVE 组相比体重增加有较小的趋势，但三组之间的体重增加没有显着差异。三组之间肝脏热休克蛋白70、Bcl-2或p53表达水平无显着差异。然而RS组的caspase-3蛋白水平显着高于其他两组。 RS 组的血液皮质醇浓度高于 RSVE 或 CON 组（p < 0.05）。 RSVE 组中最低 (p < 0.05)。 我们的研究结果表明，慢性束缚应激引起的细胞凋亡可能会被小鼠的自主运动所抑制。
To determine whether voluntary exercise (wheel running) has the potential of relieving stress. In this study, restraint stress with or without voluntary wheel running was performed for mice housed in individual cages. A total of 21 ICR male mice were assigned into control (CON), restraint stress with voluntary exercise (RSVE), or restraint stress (RS) without voluntary exercise groups (n = 7 each). No significant difference in body weight increase was found among the three groups, although CON and RS groups had a tendency of having smaller body weight increase compared to the RSVE group. No significant difference in the expression level of liver heat shock protein 70, Bcl-2, or p53 was found among the three groups. However, caspase-3 protein level in RS group was significantly higher than that in the other two groups. Blood cortisol concentration in RS was higher (p < 0.05) than that in RSVE or CON group. It was the lowest (p < 0.05) in the RSVE group. Our findings suggest that apoptosis caused by chronic restraint stress might be suppressed by voluntary exercise in mice.