MEASUREMENT OF PULMONARY EDEMA
MEASUREMENT OF PULMONARY EDEMA
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DOI：
10.1161/01.res.16.5.482
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发表时间：
1965-01-01
影响因子：
20.1
通讯作者：
BEAZELL, J
中科院分区：
文献类型：
--
作者：
PEARCE, ML;YAMASHITA, J;BEAZELL, J
比较了两种肺水肿的测量方法。第一种方法允许在体内连续测量，取决于水标记物和血管内标记物的平均通过时间的差异。第二种方法是死后测量肺总水量，并将其分配到肺血或肺血管外水。研究了三组，每组6只狗：对照组、肺静脉压升高引起的肺水肿组和四氧嘧啶引起的肺水肿组。与尸检方法相比，同位素占对照组肺血管外水的71%，高压水肿组为94%，四氧嘧啶水肿组为57%。尽管100%O2-呼吸，但通过Pa O2大幅下降测量的分流在第二组5只四氧嘧啶犬中变得明显，并且通过同位素方法测量的死后肺血管外水仅为31%。结论：同位素渡越时间法是一种在体肺水肿连续测量的有效方法。当肺水肿是由于肺静脉压升高而不是血管通透性增加时，更准确地确定水肿水。
Two methods for the measurement of pulmonary edema are compared. The 1st method, which permits serial measurements in vivo, depends on the difference in mean transit time of a water label and an intravascular label. The 2nd method is a post mortem one in which total lung water is measured and allocated to the pulmonary blood or to pulmonary extravascular water. Three groups of 6 dogs each were studied: controls, a group with pulmonary edema produced by elevating pulmonary venous pressure, and a group with pulmonary edema produced by alloxan. The isotopic as compared with the post mortem method accounted for 71% of the pulmonary extravascular water found in the controls, 94% in high pressure edema and 57% in alloxan edema. Shunting, as measured by a large fall in Pa O2 despite 100% O2-breathing, became marked in a 2nd group of 5 alloxan dogs and only 31% of the post mortem pulmonary extravascular water was measured by the isotope method. It is concluded that the isotope transit time method is a useful one for the serial measurement of pulmonary edema in vivo. The edema water is more accurately determined when pulmonary edema is due to elevated pulmonary venous pressure than to increased vascular per meability.