Increasing Heritability of BMI and Stronger Associations With the FTO Gene Over Childhood
Increasing Heritability of BMI and Stronger Associations With the FTO Gene Over Childhood
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童年时期 BMI 的遗传力不断增加，与 FTO 基因的关联性更强
DOI：
10.1038/oby.2008.434
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发表时间：
2008-12-01
期刊：
影响因子：
6.9
通讯作者：
Wardle, Jane
中科院分区：
文献类型：
--
作者：
Haworth, Claire M. A.;Carnell, Susan;Wardle, Jane
越来越多的证据表明，与儿童肥胖症增加相关的健康风险增加了了解BMI决定因素的紧迫性。对大于7，000名儿童的纵向样本中BMI重复评估的双胞胎分析表明，遗传对BMI的影响逐渐增强，遗传力从4岁的0.48增加到11岁的0.78。在同一个大型双胞胎样本中，FTO基因的一个常见变异体与BMI之间的关联随着遗传力的增加而增加，从4岁时的R（2）< 0.001到11岁时的R（2）= 0.01。这些发现表明，FTO的表达可能在整个童年时期变得更强。遗传性的增加也可能是由于儿童越来越多地选择与其遗传倾向相关的环境。
The growing evidence of health risks associated with the rise in childhood obesity adds to the urgency of understanding the determinants of BMI. Twin analyses on repeated assessments of BMI in a longitudinal sample of >7,000 children indicated that the genetic influence on BMI becomes progressively stronger, with heritability increasing from 0.48 at age 4 to 0.78 at age 11. In the same large twin sample, the association between a common variant in the FTO gene and BMI increased in parallel with the rise in heritability, going from R(2) < 0.001 at age 4 to R(2) = 0.01 at age 11. These findings suggest that expression of FTO may become stronger throughout childhood. Increases in heritability may also be due to children increasingly selecting environments correlated with their genetic propensities.