Palladium-catalyzed oxidative C-H bond acylation of N-nitrosoanilines with toluene derivatives: a traceless approach to synthesize N-alkyl-2-aminobenzophenones
Palladium-catalyzed oxidative C-H bond acylation of N-nitrosoanilines with toluene derivatives: a traceless approach to synthesize N-alkyl-2-aminobenzophenones
复制标题
钯催化 N-亚硝基苯胺与甲苯衍生物的氧化 C-H 键酰化：合成 N-烷基-2-氨基二苯甲酮的无痕方法。
DOI：
10.1039/c4cc07440h
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发表时间：
2014
影响因子：
4.9
通讯作者：
Luo Hai-Bin
中科院分区：
文献类型：
--
作者：
Wu Yinuo;Feng Ling-Jun;Lu Xiao;Kwong Fuk Yee;Luo Hai-Bin
描述了用于直接合成 N-烷基-2-氨基二苯甲酮的 N-亚硝基苯胺和甲苯衍生物的钯催化级联交叉偶联。苯胺中的N-亚硝基可以作为无痕导向基团，而甲苯衍生物在温和的反应条件下可以作为有效的酰基前体。
A palladium-catalyzed cascade cross-coupling of N-nitroso-anilines and toluene derivatives for the direct synthesis of N-alkyl-2-aminobenzophenones is described. N-nitroso groups in anilines can act as the traceless directing groups while toluene derivatives can serve as effective acyl precursors under mild reaction conditions.