Reduced joint count indices in the evaluation of rheumatoid arthritis.
Reduced joint count indices in the evaluation of rheumatoid arthritis.
复制标题
评估类风湿关节炎时关节计数指数减少。
作者：
M. Egger;D. Huth;J. Ward;J. Reading;H. Williams
在类风湿性关节炎患者的2项对照临床试验中评价了关节疾病的两种汇总指标。一项措施是完全基于临床/生物学判断的方法，其他方法结合使用可靠性和因素分析的统计方法。“信号关节”指数，总结疾病活动在2-5个关键关节，被认为是不敏感的非信号关节的分类。因此，不建议将其作为类风湿性关节炎完整关节检查的替代品。基于其有效性、可靠性、准确性、精密度和对活性药物的敏感性，发现完整关节调查的简化版本是可取的。其灵敏度可略高于或略低于全联合调查。
Two types of summary measures of joint disease were evaluated in 2 controlled clinical trials in rheumatoid arthritis patients. One measure was based solely on the clinical/biologic judgment approach; the other combined this methodology with statistical approaches using reliability and factor analyses. "Signal joint" indices, summarizing disease activity in 2-5 key joints, were found to be insensitive to deterioriation of nonsignal joints. Therefore, they are not recommended as replacements for the complete articular survey in rheumatoid arthritis. A reduced version of the complete articular survey was found to be desirable based on its validity, reliability, accuracy, precision, and sensitivity to active drugs. Its sensitivity can be slightly higher or lower than that of the full joint survey.