Effects of whole life exposure to Bisphenol A or 17α-ethinyl estradiol in uterus of nulligravida CD1 mice.
Effects of whole life exposure to Bisphenol A or 17α-ethinyl estradiol in uterus of nulligravida CD1 mice.
复制标题
终生暴露于双酚 A 或 17α-乙炔雌二醇对未怀孕 CD1 小鼠子宫的影响。
DOI：
10.1016/j.dib.2015.10.034
复制
发表时间：
2015
期刊：
影响因子：
1.2
通讯作者：
Belcher,ScottM
中科院分区：
文献类型：
--
作者：
Kendziorski,JessicaA;Belcher,ScottM
双酚A （BPA）是一种已知具有雌激素活性的内分泌干扰化学物质（EDC）。先前的研究显示，成年小鼠暴露于双酚a会增加子宫病理，并伴有免疫反应和纤维化的相关改变。本文报道了CD1小鼠从受孕到产后90天多剂量暴露于双酚a或17α-乙炔雌二醇的子宫组织病理学结果。随着子宫病理，暴露对胶原积累和F4/80阳性巨噬细胞数量的影响，作为子宫内膜和子宫肌层免疫反应的指标，被提出。这些伴随数据来自于对成年暴露的影响进行分析的后代（F1），发表在生殖毒理学手稿中，题为“成年期间暴露于内分泌干扰化学物质双酚A的小鼠子宫内膜周围纤维化的菌株特异性诱导”（doi: 10.1016/j.r oprotox .2015.08.001）。
Bisphenol A (BPA) is an endocrine disrupting chemical (EDC) with known estrogenic activity. Exposure to BPA in adult mice was shown previously to increase uterine pathology with associated alterations in the immune response and fibrosis. Reported here are uterine histopathology findings from CD1 mice exposed to BPA or 17α-ethinyl estradiol at multiple doses from conception through postnatal day 90. Along with uterine pathology, impacts of exposure on collagen accumulation and F4/80 positive macrophage numbers, as an indicator of immune response in the endometrium and myometrium, are presented. These companion data are from offspring (F1) of the dams analyzed for effects of adult exposures published in theReproductive Toxicologymanuscript titled “Strain-Specific Induction of Endometrial Periglandular Fibrosis in Mice Exposed during Adulthood to the Endocrine Disrupting Chemical Bisphenol A” (doi: 10.1016/j.reprotox.2015.08.001).