Avian CD4+CD25+ regulatory T cells: Properties and therapeutic applications
Avian CD4+CD25+ regulatory T cells: Properties and therapeutic applications
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DOI：
10.1016/j.dci.2013.04.018
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发表时间：
2013-11-01
影响因子：
2.9
通讯作者：
Selvaraj, Ramesh K.
中科院分区：
文献类型：
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作者：
Selvaraj, Ramesh K.
调节性T细胞（Regulatory T cells，Tcells）是一种专门从事免疫抑制的T细胞亚群。CD 4（+）CD 25（+）FoxP 3（+）T细胞已被表征为T细胞，并在哺乳动物中进行了广泛研究。在禽类中不存在推定的FoxP 3直系同源物的情况下，CD 4（+）CD 25（+）细胞被表征为禽类中的TcB。禽类CD 4（+）CD 25（+）细胞产生大量IL-10、TGF-β、CTLA-4和LAG-3 mRNA;缺乏IL-2 mRNA;并通过接触依赖性和非接触依赖性途径抑制体外T细胞增殖。消耗禽类CD 4（+）CD 25（+）细胞增加了CD 4（+）CD 25（-）细胞的增殖、IL-2量和IFN γ mRNA量。禽类CD 4（+）CD 25（+）细胞在炎症后立即失去其抑制特性，并在炎症消退后获得超抑制特性。虽然Treg活性可能对宿主有益，但Teptide同时抑制宿主免疫并引起某些病原体的持续感染。针对减轻Treg介导的免疫抑制的治疗可以提高宿主对这些持久性病原体的免疫力，并有益于家禽生产。(C)2013爱思唯尔有限公司保留所有权利。
Regulatory T cells (Tregs) are a subset of T cells that specialize in immune suppression. CD4(+)CD25(+)FoxP3(+) T cells have been characterized as Tregs and extensively studied in mammals. In the absence of a putative FoxP3 ortholog in avians, CD4(+)CD25(+) cells is characterized as Tregs in avians. Avian CD4(+)CD25(+) cells produce high amounts of IL-10, TGF-beta, CTLA-4, and LAG-3 mRNA; lack IL-2 mRNA; and suppress T cell proliferation in vitro through both contact-dependent and -independent pathways. Depleting avian CD4(+)CD25(+) cells increases the proliferation of, IL-2 amount, and IFN gamma mRNA amount of CD4(+)CD25(-) cells. Avian CD4(+)CD25(+) cells lose their suppressive properties immediately after inflammation and acquire supersuppressive properties once inflammation subsides. Although Treg activity could be beneficial to the host, Tregs simultaneously inhibit host immunity and cause persistent infections of certain pathogens. Therapy targeted toward alleviating Treg mediated immune suppression can improve host immunity against those persistent pathogens and benefit poultry production. (C) 2013 Elsevier Ltd. All rights reserved.