Premature myocardial infarction is associated with low serum levels of Wnt-1
Premature myocardial infarction is associated with low serum levels of Wnt-1
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DOI：
10.1016/j.atherosclerosis.2012.02.017
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发表时间：
2012-05-01
期刊：
影响因子：
5.3
通讯作者：
Speidl, Walter S.
中科院分区：
文献类型：
--
作者：
Goliasch, Georg;Wiesbauer, Franz;Speidl, Walter S.
目的：除了对糖脂代谢的影响外，Wnt信号转导通路还参与调节血管细胞的增殖、迁移和存活。此外，在一个常染色体显性遗传性早期冠状动脉疾病家系中发现了Wnt信号缺陷。这项研究的目的是调查早期冠状动脉疾病是否与WNT信号减少的特征有关。方法和结果：我们前瞻性地招募了100名连续的心肌梗死(MI)年轻幸存者
Objective: Besides its effects on glucose and lipid metabolism, the Wnt pathway has been increasingly implicated in the regulation of proliferation, migration and survival of vascular cells. In addition, defective Wnt signaling has been identified in a family with autosomal dominant early coronary artery disease. The aim of this study was to investigate whether premature coronary artery disease is associated with features of decreased Wnt signaling.Methods and results: We prospectively enrolled 100 consecutive young survivors of myocardial infarction (MI