Radiosensitization of Hs-766T Pancreatic Tumor Xenografts in Mice Dosed with Dodecafluoropentane Nano-Emulsion-Preliminary Findings.
Radiosensitization of Hs-766T Pancreatic Tumor Xenografts in Mice Dosed with Dodecafluoropentane Nano-Emulsion-Preliminary Findings.
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DOI：
10.1166/jbn.2015.1903
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发表时间：
2015-03
影响因子：
2.9
通讯作者：
Unger EC
中科院分区：
文献类型：
--
作者：
Johnson JL;Leos RA;Baker AF;Unger EC
肿瘤乏氧是放射治疗抵抗的重要介质。我们进行了一项研究，以研究基于十二碳五烯酸（DDFP）纳米乳剂（NVX-108）的氧治疗剂是否可以增加缺氧肿瘤中的肿瘤pO 2并改善放射反应。胰腺（Hs-766 T）肿瘤异种移植物在29只SCID小鼠的侧腹中生长。在用0.3、0.45和0.6 cc/kg NVX-108（2% w/vol DDFP）处理的9只小鼠中进行直接肿瘤pO 2测量，以评估肿瘤pO 2的剂量依赖性增加。将20只小鼠随机分为3组，包括对照组（未处理）、用12戈伊辐射处理的carbogen呼吸组和用12戈伊辐射和NVX-108处理的carbogen呼吸组（在辐射时以30分钟IV输注施用0.6 cc/kg NVX-108）。监测肿瘤体积以评估治疗功效。结果显示，NVX-108处理的小鼠中肿瘤pO 2增加高达400%，在0.6 cc/kg的最高剂量下观察到最大效果。相对于对照，两个治疗组中的肿瘤生长显著减少（p < 0.0001）。与carbogen加放射治疗相比，carbogen、放射和NVX-108的组合显示平均肿瘤体积减少2倍（p = 0.01）。NVX-108作为辐射敏化剂的进一步研究是必要的。
Tumor hypoxia is an important mediator of radiation therapy resistance. We conducted a study to investigate whether an oxygen therapeutic based upon dodecafluoropentane (DDFP) nano-emulsion (NVX-108) could increase tumor pO2 in hypoxic tumors and improve radiation response. Pancreatic (Hs-766T) tumor xenografts were grown in the flanks of 29 SCID mice. Direct tumor pO2 measurements were performed in 9 mice treated with 0.3, 0.45 and 0.6 cc/kg NVX-108 (2% w/vol DDFP) in order to assess the dose dependent increase in tumor pO2. Twenty mice were randomized into 3 groups including control (no treatment), carbogen breathing treated with 12 Gy radiation, and carbogen breathing treated with 12 Gy radiation and NVX-108 (0.6 cc/kg NVX-108 administered as 30 minute IV infusion at time of radiation). Tumor volume was monitored to assess treatment efficacy. Results showed that tumor pO2 increased in NVX-108 treated mice up to 400% with the greatest effect seen at the highest dose of 0.6 cc/kg. Tumor growth was significantly reduced in both treatment groups relative to controls (p < 0.0001). The combination of carbogen, radiation, and NVX-108 demonstrated a 2-fold reduction in average tumor volume compared to carbogen plus radiation treatment (p = 0.01). Further study of NVX-108 as a radiation sensitizer is warranted.
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影响因子：
11.2
作者：
Marchesi, F;Monti, P;Allavena, P
通讯作者：
Allavena, P
DOI：
10.1016/0360-3016(86)90164-1
发表时间：
1986-08-01
影响因子：
7
作者：
ROSE, C;LUSTIG, R;TEICHER, B
通讯作者：
TEICHER, B
影响因子：
11.2
作者：
Chang, Qing;Jurisica, Igor;Hedley, David W.
通讯作者：
Hedley, David W.
影响因子：
3.3
作者：
Howe, FA;Barton, SJ;Griffiths, JR
通讯作者：
Griffiths, JR
影响因子：
8.8
作者：
CHAPLIN, DJ;HORSMAN, MR;AOKI, DS
通讯作者：
AOKI, DS