Impact of Infiltrative Growth on the Outcome of Patients With Undifferentiated Pleomorphic Sarcoma and Myxofibrosarcoma
Impact of Infiltrative Growth on the Outcome of Patients With Undifferentiated Pleomorphic Sarcoma and Myxofibrosarcoma
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DOI：
10.1002/jso.23708
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发表时间：
2014-11-01
影响因子：
2.5
通讯作者：
Ishii, Takeshi
中科院分区：
文献类型：
--
作者：
Iwata, Shintaro;Yonemoto, Tsukasa;Ishii, Takeshi
背景和目的浸润性生长常见于未分化多形性肉瘤（UPS）和粘液纤维肉瘤（MFS），常与手术切缘阳性和局部失败有关。我们的研究的目的是确定是否与UPS和MFS的患者的结果与放射学的增长模式。MethodsWe回顾了89例诊断为UPS或MFS，并在我们的研究所1994年和2011年之间进行了初步手术。在术前MRI上通过放射学评估生长模式。收集临床病理因素和单因素和多因素分析进行survival.ResultsInfiltrative生长观察21例（24%），这与浅表肿瘤和手术切缘阳性。相对于非浸润性生长，浸润性生长与疾病特异性差和远处无失败生存率相关。多因素分析证实，这些因素仍然是显着的因素。非浸润性肿瘤切除不充分的患者表现出更有利的局部控制与术后放疗，虽然没有临床效益被认为是那些浸润性tumor.ConclusionsInfiltrative增长是一个不利的预后因素，不仅局部控制，而且疾病特异性和无转移生存的UPS和MFS患者。放射治疗不能挽救切除不充分的浸润性肿瘤。外科肿瘤学杂志2014 110：707-711. (c)2014 Wiley Periodicals，Inc.
Background and ObjectivesInfiltrative growth, frequently observed in undifferentiated pleomorphic sarcoma (UPS) and myxofibrosarcoma (MFS), is often associated with a positive surgical margin as well as a local failure. The purpose of our study was to determine whether the radiographic growth patterns were associated with the outcomes of patients with UPS and MFS.MethodsWe reviewed 89 patients diagnosed with UPS or MFS and underwent initial surgery at our institute between 1994 and 2011. Growth patterns were assessed radiographically on preoperative MRI. Clinicopathological factors were collected and uni- and multivariate analyses were performed for survival.ResultsInfiltrative growth was observed in 21 patients (24%), which correlated with superficial tumors and positive surgical margin. Infiltrative growth correlated with poor disease-specific and distant failure-free survivals relative to non-infiltrative growth. Multivariate analysis confirmed that these factors remained as significant factors. Patients with non-infiltrative tumors resected inadequately exhibited slightly more favorable local control with postoperative radiotherapy, although no clinical benefit was seen for those with infiltrative tumors.ConclusionsInfiltrative growth was an adverse prognostic factor for not only local control, but also disease-specific and metastasis-free survival in patients with UPS and MFS. Radiotherapy could not salvage inadequately resected infiltrative tumors. J. Surg. Oncol. 2014 110:707-711. (c) 2014 Wiley Periodicals, Inc.