Occult blood in faeces is associated with all-cause and non-colorectal cancer mortality
Occult blood in faeces is associated with all-cause and non-colorectal cancer mortality
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DOI：
10.1136/gutjnl-2018-316483
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发表时间：
2018-12-01
期刊：
影响因子：
24.5
通讯作者：
Steele, Robert J. C.
中科院分区：
文献类型：
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作者：
Libby, Gillian;Fraser, Callum G.;Steele, Robert J. C.
目的报道可检测的粪便血红蛋白（f-Hb）与结直肠癌（CRC）死亡风险和全因死亡率之间的关系。我们着手在英国人群中证实或反驳这一观察结果，并探索愈伤愈疮粪便隐血试验（gobt）阳性结果所显示的f-Hb与不同死因之间的关系。通过将2000年3月29日至2016年3月29日在苏格兰泰赛德参加ggft筛查的所有个体（134192人）的检测结果（阳性或阴性）与苏格兰国家记录数据库的死亡率数据联系起来，并随访至2016年3月30日。结果检测结果阳性的患者（n=2714）的死亡风险高于检测结果阴性的患者，从CRC: HR 7.79 (95% CI 6.13 ~ 9.89), p
Objective An association between detectable faecal haemoglobin (f-Hb) and both the risk of death from colorectal cancer (CRC) and all-cause mortality has been reported. We set out to confirm or refute this observation in a UK population and to explore the association between f-Hb, as indicated by a positive guaiac faecal occult blood test (gFOBT) result, and different causes of death.Design All individuals (134 192) who participated in gFOBT screening in Tayside, Scotland between 29/03/2000 and 29/03/2016 were studied by linking their test result (positive or negative) with mortality data from the National Records of Scotland database and following to 30/03/2016.Results Those with a positive test result (n=2714) had a higher risk of dying than those with a negative result, from CRC: HR 7.79 (95% CI 6.13 to 9.89), p