Autobiographical memory retrieval and hippocampal activation as a function of repetition and the passage of time.
Autobiographical memory retrieval and hippocampal activation as a function of repetition and the passage of time.
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DOI：
10.1155/2007/90472
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发表时间：
2007
影响因子：
3.1
通讯作者：
Ryan L
中科院分区：
文献类型：
--
作者：
Nadel L;Campbell J;Ryan L
多重痕迹理论（MTT）预测，海马记忆痕迹会随着重复记忆提取的作用而扩大和加强。我们利用功能磁共振成像测试了这一假设，比较了记忆检索与单纯时间流逝对海马激活的影响。在进行功能磁共振成像扫描时，参与者检索了一个月前、两天前或上个月多次检索过的远程自传记忆。行为分析显示，检索到的记忆细节的数量和一致性随着多次检索而增加，但不会随着时间的推移而增加。虽然所有三种检索条件都激活了通常与自传体记忆检索相关的一组相似的大脑区域，包括内侧颞叶结构，但海马激活并没有随着多次检索或时间的流逝而改变。然而，其他大脑区域的激活，包括楔前叶、外侧前额叶皮层、顶叶皮层、外侧颞叶和鼻周皮层，在多次检索后增加，但不受时间流逝的影响。这些结果对现有的长期记忆巩固理论具有重要意义。
Multiple trace theory (MTT) predicts that hippocampal memory traces expand and strengthen as a function of repeated memory retrievals. We tested this hypothesis utilizing fMRI, comparing the effect of memory retrieval versus the mere passage of time on hippocampal activation. While undergoing fMRI scanning, participants retrieved remote autobiographical memories that had been previously retrieved either one month earlier, two days earlier, or multiple times during the preceding month. Behavioral analyses revealed that the number and consistency of memory details retrieved increased with multiple retrievals but not with the passage of time. While all three retrieval conditions activated a similar set of brain regions normally associated with autobiographical memory retrieval including medial temporal lobe structures, hippocampal activation did not change as a function of either multiple retrievals or the passage of time. However, activation in other brain regions, including the precuneus, lateral prefrontal cortex, parietal cortex, lateral temporal lobe, and perirhinal cortex increased after multiple retrievals, but was not influenced by the passage of time. These results have important implications for existing theories of long-term memory consolidation.