One-year statin persistence and adherence in adults with HIV in the United States.
One-year statin persistence and adherence in adults with HIV in the United States.
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DOI：
10.1016/j.jacl.2020.11.001
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发表时间：
2021-01
影响因子：
4.4
通讯作者：
Colantonio LD
中科院分区：
文献类型：
--
作者：
Crockett KB;Wen Y;Overton ET;Jackson EA;Rosenson RS;Muntner P;Colantonio LD
美国成年人中他汀类药物的持续性和依从性较低。在美国，大多数HIV感染者对抗逆转录病毒治疗（ART）的依从性很高，但对他们的他汀类药物持续性和依从性知之甚少。我们分析了有和无HIV的成年人对他汀类药物治疗的持续性和依从性。我们分析了MarketScan数据库中2007年至2016年期间开始他汀类药物治疗的成人的索赔数据。根据年龄、性别和开始使用他汀类药物的日历年，HIV感染者（n= 5，619）与无HIV感染者（n= 22，476）的频率匹配为1比4。他汀类药物持续性定义为在开始后365天的最后90天内分发他汀类药物。高他汀类药物依从性定义为开始治疗后365天内覆盖天数比例（PDC）≥0.80。在艾滋病毒感染者中，计算了每种抗逆转录病毒疗法的PDC。研究人群的平均年龄为51岁，85.8%为男性。他汀类药物的持久性在HIV感染者和非HIV感染者中更高（72.8%比65.2%，多变量校正的患病率比1.13，95%CI 1.11-1.15）。在那些坚持使用他汀类药物的人群中，HIV感染者与非HIV感染者中他汀类药物依从性高的比例更高（69.6%对59.9%，多变量调整的患病率比1.16，95%CI 1.13-1.19）。在HIV感染者和高ART依从性（最小PDC ≥0.90）人群中，34.6%的他汀类药物治疗PDC <0.80。与未感染艾滋病毒的成年人相比，感染艾滋病毒的成年人对他汀类药物的依从性更强。然而，很高比例的成年HIV感染者对他汀类药物的依从性较低。
Statin persistence and adherence are low among US adults. Most individuals with HIV in the US have high adherence to antiretroviral therapy (ART), but less is known about their statin persistence and adherence. We analyzed persistence and adherence to statin therapy among adults with and without HIV. We analyzed claims data from adults in the MarketScan database who initiated statin therapy between 2007 and 2016. People with HIV (n=5,619) were frequency matched 1-to-4 to those without HIV (n=22,476) based on age, sex, and calendar year of statin initiation. Statin persistence was defined by having dispensed statin medication during the last 90 days of the 365 days following initiation. High statin adherence was defined as a proportion of days covered (PDC) ≥0.80 during the 365 days following initiation. Among people with HIV, the PDC for each ART was calculated. The mean age of the study population was 51 years and 85.8% were men. Statin persistence was higher among adults with versus without HIV (72.8% versus 65.2%, multivariable-adjusted prevalence ratio 1.13, 95%CI 1.11–1.15). Among those who were persistent, a higher proportion of people with versus without HIV had high statin adherence (69.6% versus 59.9%, multivariable-adjusted prevalence ratio 1.16, 95%CI 1.13–1.19). Among people with HIV and high ART adherence (minimum PDC ≥0.90), 34.6% had a PDC for statin therapy <0.80. Adults with HIV were more persistent and adherent to statin medications versus those without HIV. However, a high proportion of adults with HIV had low statin adherence.
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DOI：
10.1097/maj.0000000000000292
发表时间：
2014-08
期刊：
The American journal of the medical sciences
影响因子：
--
作者：
Gamboa CM;Safford MM;Levitan EB;Mann DM;Yun H;Glasser SP;Woolley JM;Rosenson R;Farkouh M;Muntner P
通讯作者：
Muntner P
影响因子：
4.9
作者：
Krousel-Wood M;Holt E;Joyce C;Ruiz R;Dornelles A;Webber LS;Morisky DE;Frohlich ED;Re RN;He J;Whelton PK;Muntner P
通讯作者：
Muntner P
影响因子：
3.3
作者：
Mayer, Kenneth H.;Loo, Stephanie;McBurnie, Mary Ann
通讯作者：
McBurnie, Mary Ann
影响因子：
4.8
作者：
Lewey, Jennifer;Shrank, William H.;Choudhry, Niteesh K.
通讯作者：
Choudhry, Niteesh K.
影响因子：
3
作者：
Elixhauser, A;Steiner, C;Coffey, RN
通讯作者：
Coffey, RN