Association and cumulative effects of GWAS-identified genetic variants for nonsyndromic orofacial clefts in a Chinese population
Association and cumulative effects of GWAS-identified genetic variants for nonsyndromic orofacial clefts in a Chinese population
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GWAS 鉴定的中国人群非综合征性口颌裂遗传变异的关联和累积效应
DOI：
10.1002/em.21773
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发表时间：
2013
影响因子：
2.8
通讯作者：
Wang Lin
中科院分区：
文献类型：
--
作者：
Pan Yongchu;Han Yue;Zhang Hongchuang;Zhou Lian;Li D;an;Cai Qi;Ma Junqing;Zhang Weibing;Wang Lin
A recent genome‐wide meta‐analysis identified six new susceptible genetic variants for nonsyndromic orofacial clefts (NSOC), but it was still unknown whether these newly identified variants were associated with NSOC susceptibility in Chinese populations. In this study, we genotyped these variants in a case‐control study of 602 NSOC cases and 605 controls and found that four of these variants (rs7590268, rs7632427, rs12543318, and rs1873147) were associated with susceptibility to NSOC. We further investigated the cumulative effects of these four variants and found a dose‐dependent increase in risk with the number of variant alleles. Furthermore, an association was observed between rs7590268 and a family history of NSOC. Our results provide confirmative evidence that these risk loci contribute to NSOC susceptibility in Chinese populations. Environ. Mol. Mutagen. 54:261–267, 2013. © 2013 Wiley Periodicals, Inc.
