Effects of environment on compensatory mutations to ameliorate costs of antibiotic resistance
Effects of environment on compensatory mutations to ameliorate costs of antibiotic resistance
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DOI：
10.1126/science.287.5457.1479
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发表时间：
2000-02-25
期刊：
影响因子：
56.9
通讯作者：
Andersson, DI
中科院分区：
文献类型：
--
作者：
Björkman, J;Nagaev, I;Andersson, DI
大多数类型的抗生素耐药性对细菌适应性造成生物成本。这些成本可以通过在实验宿主或实验室培养基中耐药细菌进化过程中的第二位点突变来补偿，通常不会丧失耐药性。根据细菌是在小鼠中还是在实验室培养基中连续传代而进化，选择不同的适应性补偿突变。突变谱的这种差异是由生长条件特异性形成或补偿突变体的选择引起的。这些结果表明，细菌进化以减少抗生素耐药性的成本可以在宿主内外采取不同的轨迹。
Most types of antibiotic resistance impose a biological cost on bacterial fitness. These costs can be compensated, usually without Loss of resistance, by second-site mutations during the evolution of the resistant bacteria in an experimental host or in a Laboratory medium. Different fitness-compensating mutations were selected depending on whether the bacteria evolved through serial passage in mice or in a Laboratory medium. This difference in mutation spectra was caused by either a growth condition-specific formation or selection of the compensated mutants. These results suggest that bacterial evolution to reduce the costs of antibiotic resistance can take different trajectories within and outside a host.