Determining the effect of cardiac blood volume on accuracy of uptake rate constants by simulation.
Determining the effect of cardiac blood volume on accuracy of uptake rate constants by simulation.
复制标题
通过模拟确定心脏血容量对摄取率常数准确性的影响。
DOI：
10.1088/1361-6560/ace0f1
复制
发表时间：
2023
影响因子：
3.5
通讯作者：
Metzler,SD
中科院分区：
文献类型：
--
作者：
Johnson,LC;Guerraty,MA;Moore,SC;Metzler,SD
Objective.人们对使用小鼠模型更好地了解冠状动脉微血管疾病非常感兴趣。典型的量化需要动态成像来估计示踪剂从血液移动到心肌中的速率常数K1。除了K1之外，还期望确定血液体积分数V，如果已知的话，其允许K1的更准确拟合。我们以前发表的动力学建模软件没有考虑V的影响。
Objective. There is great interest in better understanding coronary microvascular disease using mouse models. Typical quantification requires dynamic imaging to estimate the rate constant K 1 of the tracer moving from the blood into the myocardium. In addition to K 1, it is also desirable to determine blood volume fraction V, which if known allows for more accurate fitting of K 1. Our previously published kinetic modeling software did not consider the effect of V. To ensure a better fit of experimental data to the model for myocardial