Report on the first SLFN11 monothematic workshop: from function to role as a biomarker in cancer.
Report on the first SLFN11 monothematic workshop: from function to role as a biomarker in cancer.
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DOI：
10.1186/s12967-017-1296-3
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发表时间：
2017-10-02
影响因子：
7.4
通讯作者：
Zoppoli G
中科院分区：
文献类型：
--
作者：
Ballestrero A;Bedognetti D;Ferraioli D;Franceschelli P;Labidi-Galy SI;Leo E;Murai J;Pommier Y;Tsantoulis P;Vellone VG;Zoppoli G
SLFN 11是最近发现的具有DNA/RNA解旋酶功能的蛋白质。SLFN 11首先与胸腺细胞的成熟相关，后来被两个独立的组与DNA损伤剂如拓扑异构酶I和II抑制剂、铂化合物和其他烷化剂的抗性因果相关，使其成为生物标志物开发的有吸引力的分子。后来，SLFN 11与人类细胞中的抗病毒反应和干扰素产生有关，在免疫和化疗之间建立了潜在的联系。最近，我们证明了SLN 11作为生物标志物预测卵巢癌对卡铂/紫杉醇联合治疗敏感性的潜在作用。本手稿报告了关于SLFN 11的第一次国际专题研讨会。来自世界各地的几位研究人员，直接积极参与SLFN 11的发现，功能表征和研究，其生物标志物和药用特性聚集在一起，分享他们对SLFN 11当前知识进展的看法。该手稿的目的是总结作者的发言和研讨会产生的主要信息。
SLFN11 is a recently discovered protein with a putative DNA/RNA helicase function. First identified in association with the maturation of thymocytes, SLFN11 was later causally associated, by two independent groups, with the resistance to DNA damaging agents such as topoisomerase I and II inhibitors, platinum compounds, and other alkylators, making it an attractive molecule for biomarker development. Later, SLFN11 was linked to antiviral response in human cells and interferon production, establishing a potential bond between immunity and chemotherapy. Recently, we demonstrated the potential role of SLN11 as a biomarker to predict sensitivity to the carboplatin/taxol combination in ovarian cancer. The present manuscript reports on the first international monothematic workshop on SLFN11. Several researchers from around the world, directly and actively involved in the discovery, functional characterization, and study of SLFN11 for its biomarker and medicinal properties gathered to share their views on the current knowledge advances concerning SLFN11. The aim of the manuscript is to summarize the authors’ interventions and the main take-home messages resulting from the workshop.
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影响因子：
64.8
作者：
Curtis, Christina;Shah, Sohrab P.;Chin, Suet-Feung;Turashvili, Gulisa;Rueda, Oscar M.;Dunning, Mark J.;Speed, Doug;Lynch, Andy G.;Samarajiwa, Shamith;Yuan, Yinyin;Graef, Stefan;Ha, Gavin;Haffari, Gholamreza;Bashashati, Ali;Russell, Roslin;McKinney, Steven;Langerod, Anita;Green, Andrew;Provenzano, Elena;Wishart, Gordon;Pinder, Sarah;Watson, Peter;Markowetz, Florian;Murphy, Leigh;Ellis, Ian;Purushotham, Arnie;Borresen-Dale, Anne-Lise;Brenton, James D.;Tavare, Simon;Caldas, Carlos;Aparicio, Samuel
通讯作者：
Aparicio, Samuel
影响因子：
--
作者：
Murai J;Feng Y;Yu GK;Ru Y;Tang SW;Shen Y;Pommier Y
通讯作者：
Pommier Y
DOI：
10.1111/j.1525-1438.2005.00130.x
发表时间：
2005-09-01
影响因子：
4.8
作者：
Duffy, MJ;Bonfrer, JM;Zwirner, M
通讯作者：
Zwirner, M
影响因子：
16
作者：
Ciccia A;Elledge SJ
通讯作者：
Elledge SJ
影响因子：
5.7
作者：
Murai J;Huang SY;Renaud A;Zhang Y;Ji J;Takeda S;Morris J;Teicher B;Doroshow JH;Pommier Y
通讯作者：
Pommier Y