Ambient air pollution and homocysteine: Current epidemiological evidence and a call for further research
Ambient air pollution and homocysteine: Current epidemiological evidence and a call for further research
复制标题
环境空气污染和同型半胱氨酸：当前的流行病学证据和进一步研究的呼吁
DOI：
10.1016/j.envres.2020.109679
复制
发表时间：
2020
影响因子：
8.3
通讯作者：
Guang-Hui Dong
中科院分区：
文献类型：
--
作者：
Bo-Yi Yang;Tong-Xing Shi;Ya-Na Luo;Xiao-Xuan Liu;Tianyu Zhao;Michael S Bloom;Hai-Zhan Jiang;Joachim Heinrich;Shu-Jun Fan;Guang-Hui Dong
血液同型半胱氨酸(Hcy)升高是心血管疾病的独立危险因素。越来越多的研究评估了空气污染和血液同型半胱氨酸水平之间的联系，但结果并不一致。到目前为止，尚未对已发表的研究进行系统的综述。我们的目的是提供这些研究的全面概述。我们系统地检索了三个国际数据库(PubMed、Web of Science和Embase)和四个中国数据库(万方、CNKI、CBM和VIP)，寻找2019年12月之前发表的同行评议的流行病学研究，调查环境空气污染物与Hcy水平之间的关系。我们筛选文献，提取数据，评估方法质量，并评估纳入研究的偏倚风险。在确定的1157篇文章中，有10篇最终纳入了这项系统评价。大多数是横断面研究，是在发达国家进行的。空气动力学直径小于2.5μm(PM2.5)和/或10μm(PM10)的颗粒物在所有纳入的研究中都被调查。总体而言，证据普遍支持较高的PM浓度和较高的Hcy水平之间的正相关。然而，研究参与者、研究设计、暴露时间、颗粒物成分和来源方面的高度异质性，一些研究的方法质量较低，可能存在较高的偏见风险，以及有限的文献数量，使我们无法得出可靠的结论。只有一两项研究探索了同型半胱氨酸和气体污染物之间的联系，结果并不确定。此外，还需要精心设计的研究来验证空气污染和同型半胱氨酸之间的联系。
Elevated blood homocysteine (Hcy) is an independent risk factor for cardiovascular disease. A growing number of studies have evaluated the link between air pollution and blood Hcy levels, but the results are inconsistent. To date, no systematic review of the published studies has been conducted yet. We aimed to provide a comprehensive overview of these studies. We systematically searched three international databases (PubMed, Web of Science, and Embase) and four Chinese databases (Wanfang, CNKI, CBM, and VIP) for peer-reviewed epidemiological studies investigating associations between ambient air pollutants and Hcy levels published before December 2019. We screened literature, extracted data, assessed methodological quality, and evaluated the risk of bias of the included studies. Of 1157 identified articles, 10 were finally included in this systematic review. Most were cross-sectional studies and were performed in developed countries. Particulate matter with aerodynamic diameters less than 2.5 μm (PM2.5) and/or 10 μm (PM10) were investigated in all of the included studies. Overall, the evidence generally supports a positive association between higher PM concentrations and elevated Hcy levels. However, high heterogeneity in terms of study participants, study design, exposure duration, and particle components and sources, low methodological quality and probable high risk of bias in some studies, and limited literature number precluded us from drawing a robust conclusion. Associations between Hcy and gaseous pollutants were explored in only one or two studies, and the results were inconclusive. Additional, well-designed studies remain required to validate the association between air pollution and Hcy.