Impaired coronary flow and ventricular function in hearts of hypertensive rats.
Impaired coronary flow and ventricular function in hearts of hypertensive rats.
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高血压大鼠心脏冠状动脉血流和心室功能受损。
DOI：
10.1093/cvr/17.9.553
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发表时间：
1983
影响因子：
10.8
通讯作者：
Scheuer,J
中科院分区：
文献类型：
--
作者：
Alfaro,A;Schaible,TF;Malhotra,A;Yipintsoi,T;Scheuer,J
用左肾动脉夹闭法建立高血压大鼠心脏模型（血压> 150 mmHg），并与假手术对照组进行心脏实验。在系列I中，在手术后第4、9至10和16至17周在隔离的工作心脏装置中研究心脏功能。在系列II中，在手术后第6至9天以及第4周和第10周，研究了常氧和缺氧逆行灌注期间的冠状动脉血流。在系列I中，与对照组相比，高血压患者在第4周和第9 - 10周的体重较低，而在每个时期的左心室重量较高。与对照组相比，高血压患者的心功能受到抑制，通过较低的每搏输出量、峰值左心室收缩压、每搏作功、射血分数、正dP/dt、峰值主动脉血流和最大血流加速度进行测量。舒张率（通过负dP/dt测量）也被抑制。高血压患者的心脏冠状动脉流量和MV 02显著降低，氧提取率和流出液乳酸/丙酮酸比值增加。高血压患者的LVEDP显著升高，而高血压患者和对照组的LVEDV（ml）相似。高血压患者术后9 ~ 10周和16 ~ 17周心肌肌动球蛋白ATP酶活性降低。在系列II中，当心脏逆行灌注时，高血压患者的冠状动脉流量低于对照组，在第6至9天和第4周的常氧期间，以及在所有时间段的缺氧期间。研究结果表明，受损的冠状动脉血管储备在大鼠高血压发展的几天内发展，这可能与心室功能受损有关。
Hearts of rats made hypertensive (BP> 150 mmHg) by left renal artery clipping and sham operated controls were studied in two series of experiments. In series I, cardiac function was studied in an isolated working heart apparatus at weeks 4, 9 to 10 and 16 to 17 post-surgery. In series II, coronary flow was studied during normoxic and anoxic retrograde perfusions at days 6 to 9 and at weeks 4 and 10 post-surgery. In series I, when compared with controls, hypertensives had lower body weights at weeks 4 and 9 to 10, and higher left ventricular weights at each period. Heart function was depressed for hypertensives when compared with controls as measured by lower stroke volume, peak left ventricular systolic pressure, stroke work, ejection fraction, positive dP/dt, peak aortic flow, and maximal flow acceleration. Relaxation rate as measured by negative dP/dt was also depressed. Hearts from hypertensives had significantly lower coronary flows and MV02, and increased percent oxygen extraction and effluent lactate/pyruvate ratios. LVEDP was significantly elevated for hypertensives, when LVEDV (ml) was similar for hypertensives and controls. Myocardial actomyosin ATPase activity was depressed for hypertensives at weeks 9 to 10 and 16 to 17 post-surgery. In series II, when hearts were perfused retrogradely, coronary flow was lower for hypertensives than for controls during normoxia at days 6 to 9 and at week 4, and during anoxia at all time periods. The findings demonstrate that impaired coronary vascular reserve develops within days of the development of hypertension in rats, and this can be associated with impaired ventricular function.