The relationships between blood lead levels and serum follicle stimulating hormone and luteinizing hormone in the National Health and Nutrition Examination Survey 1999-2002
The relationships between blood lead levels and serum follicle stimulating hormone and luteinizing hormone in the National Health and Nutrition Examination Survey 1999-2002
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DOI：
10.1016/j.reprotox.2011.05.012
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发表时间：
2011-11-01
影响因子：
3.3
通讯作者：
Feng, Huiling A.
中科院分区：
文献类型：
--
作者：
Krieg, Edward F., Jr.;Feng, Huiling A.
从1999-2002年全国健康和营养检查调查中，对35-60岁具有全国代表性的女性样本中血铅水平与血清卵泡刺激素和黄体生成素之间的关系进行了评估。女性血铅水平在0.2~17.0微克/分升之间。估计的几何平均值为1.4微克/分升，估计的算术平均值为1.6微克/分升。随着血铅水平的升高，绝经后妇女、摘除双侧卵巢妇女和绝经前妇女血清卵泡刺激素水平升高。在绝经后妇女和切除双侧卵巢的妇女中，促黄体激素浓度随着血铅水平的升高而增加。与此相关的最低血铅浓度为卵泡刺激素0.9mU g/dL，黄体生成激素3.2mU g/dL。铅可能直接或间接作用于卵巢和非卵巢部位，增加卵泡刺激素和黄体生成素的浓度。由爱思唯尔公司出版。
The relationships between blood lead levels and serum follicle stimulating hormone and luteinizing hormone were assessed in a nationally representative sample of women, 35-60 years old, from the National Health and Nutrition Examination Survey 1999-2002. The blood lead levels of the women ranged from 0.2 to 17.0 mu g/dL. The estimated geometric mean was 1.4 mu g/dL, and the estimated arithmetic mean was 1.6 mu g/dL. As the blood lead level increased, the concentration of serum follicle stimulating hormone increased in post-menopausal women, women who had both ovaries removed, and pre-menopausal women. The concentration of luteinizing hormone increased as blood lead level increased in postmenopausal women and women who had both ovaries removed. The lowest concentrations of blood lead at which a relationship was detected were 0.9 mu g/dL for follicle stimulating hormone and 3.2 mu g/dL for luteinizing hormone. Lead may act directly or indirectly at ovarian and non-ovarian sites to increase the concentrations of follicle stimulating hormone and luteinizing hormone. Published by Elsevier Inc.