CD56(+) LYMPHOID-CELLS IN HUMAN 1ST-TRIMESTER PREGNANCY DECIDUA AS A SOURCE OF NOVEL TRANSFORMING GROWTH FACTOR-BETA(2)-RELATED IMMUNOSUPPRESSIVE FACTORS
CD56(+) LYMPHOID-CELLS IN HUMAN 1ST-TRIMESTER PREGNANCY DECIDUA AS A SOURCE OF NOVEL TRANSFORMING GROWTH FACTOR-BETA(2)-RELATED IMMUNOSUPPRESSIVE FACTORS
复制标题
DOI：
10.1093/oxfordjournals.humrep.a138436
复制
发表时间：
1994-12-01
影响因子：
6.1
通讯作者：
STARKEY, P
中科院分区：
文献类型：
--
作者：
CLARK, DA;VINCE, G;STARKEY, P
The lymphomyeloid cells isolated from normal first trimester pregnancy decidua may be separated into a CD56(+) population of natural killer (NK)-lineage cells with the morphology of granulated lymphocytes, and a CD56(-) population which includes other cell types. Unlike CD56(+) NK cells in peripheral blood, decidual CD56(+) cells lack type III Fc receptors (CD16) and did not express significant levels of either type I FcR (CD64) or type II FcR (CDw32). By contrast to the decidual CD56(-) cells, CD56(+) cells could release biologically active transforming growth factor (TCF)-beta in vitro, detectable using an normal rat kidney fibroblast colony-forming assay. The CD56(+) cells could be stained using an antibody specific for TGF-beta(2), and similarly staining cells could be detected in intact biopsies of normal pregnancy decidua. Bioactive TGF-beta is known to suppress the generation of cytotoxic cells in vitro, and high performance liquid chromatography fractionation of supernatants conditioned by CD56(+) but not CD56(-) cells contained reproducible peaks of immunosuppressive activity at 40-45 and 15-20 kDa, similar to the TGF-beta(2) immunosuppressive activity in supernatants conditioned by unfractionated decidua.
