Brown Adipose Tissue Transplantation Reverses Obesity in Ob/Ob Mice
Brown Adipose Tissue Transplantation Reverses Obesity in Ob/Ob Mice
复制标题
棕色脂肪组织移植逆转 Ob/Ob 小鼠的肥胖
DOI：
10.1210/en.2014-1598
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发表时间：
2015-07-01
期刊：
影响因子：
4.8
通讯作者：
Jin, Wanzhu
中科院分区：
文献类型：
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作者：
Liu, Xiaomeng;Wang, Siping;Jin, Wanzhu
越来越多的证据表明，在饮食诱导肥胖的小鼠模型中，棕色脂肪组织（BAT）移植可增强全身能量代谢。然而，BAT对遗传性肥胖小鼠是否也有此类有益作用仍不清楚。为解决这一问题，我们将C57/BL6小鼠的BAT移植到年龄和性别匹配的瘦素缺乏型Ob/Ob小鼠的背部皮下区域。有趣的是，BAT移植导致体重增加显著减少，同时耗氧量增加，全身脂肪量减少，从而改善了胰岛素抵抗和肝脏脂肪变性。此外，BAT移植提高了循环脂联素水平，而降低了循环中游离T - 3和T - 4的水平，这两种物质可调节外周组织对甲状腺激素的敏感性。BAT移植还增加了皮下和附睾（EP）白色脂肪组织中β - 3 - 肾上腺素能受体及脂肪酸氧化相关基因的表达。因此，BAT移植增加了全身产热。综上所述，我们的研究结果表明，BAT移植可通过激活内源性BAT来减轻肥胖及其相关疾病。
Increasing evidence indicates that brown adipose tissue ( BAT) transplantation enhances whole-body energy metabolism in a mouse model of diet-induced obesity. However, it remains unclear whether BAT also has such beneficial effects on genetically obese mice. To address this issue, we transplanted BAT from C57/BL6 mice into the dorsal subcutaneous region of age- and sex-matched leptin deficient Ob/Ob mice. Interestingly, BAT transplantation led to a significant reduction of body weight gain with increased oxygen consumption and decreased total body fat mass, resulting in improvement of insulin resistance and liver steatosis. In addition, BAT transplantation increased the level of circulating adiponectin, whereas it reduced the levels of circulating free T-3 and T-4, which regulate thyroid hormone sensitivity in peripheral tissues. BAT transplantation also increased beta-3-ad-renergic receptor and fatty acidoxidation related gene expression in subcutaneous and epididymal (EP) white adipose tissue. Accordingly, BAT transplantation increased whole-body thermogenesis. Taken together our results demonstrate that BAT transplantation may reduce obesity and its related diseases by activating endogenous BAT.