Sex-related impairment of memory for emotional events with β-adrenergic blockade
Sex-related impairment of memory for emotional events with β-adrenergic blockade
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DOI：
10.1016/s1074-7427(02)00019-9
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发表时间：
2003-01-01
影响因子：
2.7
通讯作者：
van Stegeren, A
中科院分区：
文献类型：
--
作者：
Cahill, L;van Stegeren, A
根据最近的证据表明杏仁核功能在情绪事件记忆中存在与性别相关的偏侧化，以及大量证据表明大脑半球在处理情况的全局（中央）与局部（细节）方面有专门化，以及杏仁核的记忆调节功能对β-肾上腺素受体激活的依赖性，我们预测了β-肾上腺素受体拮抗剂（普萘洛尔）对情绪激动故事的长期记忆的不同影响男人和女人。具体来说，我们预测，相对于安慰剂，普萘洛尔会损害男性对故事情节核心信息的记忆，但不会损害对外围故事细节的记忆。相反，普萘洛尔会损害女性对外围细节的记忆，但不会损害对核心信息的记忆。在这里，我们通过对普萘洛尔对激动人心的故事记忆的影响的两项已发表研究的数据进行新颖的分析，证实了这一预测。这些发现表明，β-肾上腺素能阻断会导致与性别相关的情绪信息记忆障碍。此外，他们还支持这样的假设：在这种范式中，情绪唤醒通过激活右杏仁核/半球功能增强男性对中心信息的长期记忆，并通过激活左杏仁核/半球功能增强女性对外围细节的长期记忆。 (C) 2002 年爱思唯尔科学（美国）。版权所有。
On the basis of recent evidence indicating a sex-related lateralization of amygdala function in memory for emotional events, together with substantial evidence suggesting hemispheric specialization in processing global (central) versus local (detail) aspects of a situation, and the established dependence of the amygdala's memory modulating function on beta-adrenergic receptor activation, we predicted differential effects of a beta-adrenergic receptor antagonist (propranolol) on long-term memory for an emotionally arousing story in men and women. Specifically, we predicted that, relative to placebo, propranolol would impair memory for information central to the story line, but not memory for peripheral story details in men. Conversely, propranolol would impair memory for peripheral details, but not for central information in women. Here we confirm this prediction with a novel analysis of data from our two published studies of propranolol's effect on memory for an emotionally arousing story. These findings demonstrate a sex-related impairment of memory for emotional information by beta-adrenergic blockade. Additionally, they provide support for the hypothesis that, in this paradigm, emotional arousal enhances long-term memory for central information in men via activation of right amygdala/hemisphere function, and enhances long-term memory for peripheral details in women via activation of left amygdala/hemisphere function. (C) 2002 Elsevier Science (USA). All rights reserved.