Mucosal-Associated Invariant T Cells in Autoimmune Diseases.
Mucosal-Associated Invariant T Cells in Autoimmune Diseases.
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DOI：
10.3389/fimmu.2018.01333
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发表时间：
2018
影响因子：
7.3
通讯作者：
Miyake S
中科院分区：
文献类型：
--
作者：
Chiba A;Murayama G;Miyake S
粘膜相关不变T细胞（MAIT）是受MHC相关分子1（MR 1）限制的先天性T细胞。MAIT细胞在人类中表达半不变T细胞受体TRAV 1 -2-TRAJ 33/12/20，在小鼠中表达TRAV 1-TRAJ 33。MAIT细胞识别由MR 1呈递的维生素B2生物合成衍生物。与其他先天性淋巴细胞类似，MAIT细胞在缺乏外源性抗原的情况下也被细胞因子激活。MAIT细胞具有产生细胞因子（如IFNγ、TNFα和IL-17）和细胞毒性蛋白（包括穿孔素和颗粒酶B）的能力。MAIT细胞最初以其在肠道粘膜组织中的优先位置命名，但它们在其他外周器官中也很丰富，包括肝脏和肺。在人类中，MAIT细胞在外周血中的频率很高，这些细胞占循环CD 3+细胞的约5%。它们在组织中的丰富性和刺激后的快速激活导致了对其在各种类型的免疫疾病中的功能的极大兴趣。在这篇综述中，首先，我们将简要介绍MAIT细胞生物学的关键信息，以便更好地了解它们在免疫反应中的作用，然后描述MAIT细胞如何与人类自身免疫和其他免疫疾病相关。此外，我们将讨论他们的功能的基础上的信息，从动物模型的自身免疫性和免疫性疾病。
Mucosal-associated invariant T (MAIT) cells are innate T cells restricted by MHC-related molecule 1 (MR1). MAIT cells express semi-invariant T-cell receptors TRAV1-2-TRAJ33/12/20 in humans and TRAV1-TRAJ33 in mice. MAIT cells recognize vitamin B2 biosynthesis derivatives presented by MR1. Similar to other innate lymphocytes, MAIT cells are also activated by cytokines in the absence of exogenous antigens. MAIT cells have the capacity to produce cytokines, such as IFNγ, TNFα, and IL-17, and cytotoxic proteins, including perforin and granzyme B. MAIT cells were originally named after their preferential location in the mucosal tissue of the gut, but they are also abundant in other peripheral organs, including the liver and lungs. In humans, the frequency of MAIT cells is high in peripheral blood, and these cells constitute approximately 5% of circulating CD3+ cells. Their abundance in tissues and rapid activation following stimulation have led to great interest in their function in various types of immune diseases. In this review, first, we will briefly introduce key information of MAIT cell biology required for better understating their roles in immune responses, and then describe how MAIT cells are associated with autoimmune and other immune diseases in humans. Moreover, we will discuss their functions based on information from animal models of autoimmune and immunological diseases.
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影响因子：
8
作者：
Gibbs A;Leeansyah E;Introini A;Paquin-Proulx D;Hasselrot K;Andersson E;Broliden K;Sandberg JK;Tjernlund A
通讯作者：
Tjernlund A
影响因子：
8
作者：
Fergusson JR;Hühn MH;Swadling L;Walker LJ;Kurioka A;Llibre A;Bertoletti A;Holländer G;Newell EW;Davis MM;Sverremark-Ekström E;Powrie F;Capone S;Folgori A;Barnes E;Willberg CB;Ussher JE;Klenerman P
通讯作者：
Klenerman P
影响因子：
15.9
作者：
Cui, Yue;Franciszkiewicz, Katarzyna;Lantz, Olivier
通讯作者：
Lantz, Olivier
影响因子：
5.5
作者：
Cho, Young-Nan;Kee, Seung-Jung;Park, Yong-Wook
通讯作者：
Park, Yong-Wook
影响因子：
3.7
作者：
Harms, Robert Z.;Lorenzo, Kristina M.;Sarvetnick, Nora E.
通讯作者：
Sarvetnick, Nora E.